(1S,2R,4S,5R)-7-(tert-Butyl-diphenyl-silanyloxy)-4,5-dimethyl-1-((2R,4aR,7R,8aR,9aS,10aS)-2-phenyl-octahydro-1,3,8,10-tetraoxa-anthracen-7-yl)-heptane-1,2-diol

Base Information

• Chemical Name: (1S,2R,4S,5R)-7-(tert-Butyl-diphenyl-silanyloxy)-4,5-dimethyl-1-((2R,4aR,7R,8aR,9aS,10aS)-2-phenyl-octahydro-1,3,8,10-tetraoxa-anthracen-7-yl)-heptane-1,2-diol
• CAS No.: 181489-41-8
• Molecular Formula: C₄₁H₅₆O₇Si
• Molecular Weight: 688.977

Synonyms:(1S,2R,4S,5R)-7-(tert-Butyl-diphenyl-silanyloxy)-4,5-dimethyl-1-((2R,4aR,7R,8aR,9aS,10aS)-2-phenyl-octahydro-1,3,8,10-tetraoxa-anthracen-7-yl)-heptane-1,2-diol

Chemical Property of (1S,2R,4S,5R)-7-(tert-Butyl-diphenyl-silanyloxy)-4,5-dimethyl-1-((2R,4aR,7R,8aR,9aS,10aS)-2-phenyl-octahydro-1,3,8,10-tetraoxa-anthracen-7-yl)-heptane-1,2-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R,4S,5R)-7-(tert-Butyl-diphenyl-silanyloxy)-4,5-dimethyl-1-((2R,4aR,7R,8aR,9aS,10aS)-2-phenyl-octahydro-1,3,8,10-tetraoxa-anthracen-7-yl)-heptane-1,2-diol

There total 16 articles about (1S,2R,4S,5R)-7-(tert-Butyl-diphenyl-silanyloxy)-4,5-dimethyl-1-((2R,4aR,7R,8aR,9aS,10aS)-2-phenyl-octahydro-1,3,8,10-tetraoxa-anthracen-7-yl)-heptane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S,4S,5R,6S)-3,5-Bis-benzyloxy-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-4-ol (35303-86-7) → (1S,2R,4S,5R)-7-(tert-Butyl-diphenyl-silanyloxy)-4,5-dimethyl-1-((2R,4aR,7R,8aR,9aS,10aS)-2-phenyl-octahydro-1,3,8,10-tetraoxa-anthracen-7-yl)-heptane-1,2-diol (181489-41-8)

Guidance literature:

Multi-step reaction with 12 steps

1: 1.) NaH, CS₂, MeI, 2.) Bu₃SnH, AIBN / 1.) THF, 23 deg C, 2.) toluene, 110 deg C

2: 70 percent / 1N aq. HCl / acetic acid / 60 °C

3: 60 percent / (COCl)2, DMSO / CH₂Cl₂ / -78 °C

4: tetrahydrofuran / -78 °C

5: Et₃SiH, BF₃*Et₂O / CH₂Cl₂ / -20 °C

6: 1.) catecholborane, (PPh₃)RhCl, 2.) 30percent aq. H₂O₂, 3 N aq. NaOH / 1.) THF, 23 deg C, 2.) 23 deg C

7: 80 percent / CrO₃, H₂SO₄

8: 85 percent / H₂ / Pd(OH)2/C / methanol / 23 °C

9: 90 percent / p-TsOH / dimethylformamide / 50 °C

10: 95 percent / CSA / benzene / 80 °C

11: 1.) n-BuLi, 2.) Et₃SiH, BF₃*Et₂O, 3.) Ph₃SnH, BEt₃, 4.) NIS, 5.) n-BuLi

12: OsO₄, NMO / H₂O; acetone; 2-methyl-propan-2-ol / 23 °C

With chromium(VI) oxide; hydrogenchloride; triethylsilane; carbon disulfide; sodium hydroxide; N-iodo-succinimide; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); triethyl borane; (PPh₃)RhCl; sulfuric acid; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; triphenylstannane; hydrogen; dihydrogen peroxide; tri-n-butyl-tin hydride; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; methyl iodide; benzo[1,3,2]dioxaborole; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; benzene;

DOI:10.1021/ja961230+

Reference yield:

2,4,6-tri-O-benzyl-3-deoxy-α-D-methylglucopyranoside (90124-36-0) → (1S,2R,4S,5R)-7-(tert-Butyl-diphenyl-silanyloxy)-4,5-dimethyl-1-((2R,4aR,7R,8aR,9aS,10aS)-2-phenyl-octahydro-1,3,8,10-tetraoxa-anthracen-7-yl)-heptane-1,2-diol (181489-41-8)

Guidance literature:

Multi-step reaction with 11 steps

1: 70 percent / 1N aq. HCl / acetic acid / 60 °C

2: 60 percent / (COCl)2, DMSO / CH₂Cl₂ / -78 °C

3: tetrahydrofuran / -78 °C

4: Et₃SiH, BF₃*Et₂O / CH₂Cl₂ / -20 °C

5: 1.) catecholborane, (PPh₃)RhCl, 2.) 30percent aq. H₂O₂, 3 N aq. NaOH / 1.) THF, 23 deg C, 2.) 23 deg C

6: 80 percent / CrO₃, H₂SO₄

7: 85 percent / H₂ / Pd(OH)2/C / methanol / 23 °C

8: 90 percent / p-TsOH / dimethylformamide / 50 °C

9: 95 percent / CSA / benzene / 80 °C

10: 1.) n-BuLi, 2.) Et₃SiH, BF₃*Et₂O, 3.) Ph₃SnH, BEt₃, 4.) NIS, 5.) n-BuLi

11: OsO₄, NMO / H₂O; acetone; 2-methyl-propan-2-ol / 23 °C

With chromium(VI) oxide; hydrogenchloride; triethylsilane; sodium hydroxide; N-iodo-succinimide; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; oxalyl dichloride; triethyl borane; (PPh₃)RhCl; sulfuric acid; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; triphenylstannane; hydrogen; dihydrogen peroxide; toluene-4-sulfonic acid; dimethyl sulfoxide; benzo[1,3,2]dioxaborole; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; benzene;

DOI:10.1021/ja961230+

Reference yield:

2,4,6-tri-O-benzyl-3-deoxy-D-ribo-hexopyranose → (1S,2R,4S,5R)-7-(tert-Butyl-diphenyl-silanyloxy)-4,5-dimethyl-1-((2R,4aR,7R,8aR,9aS,10aS)-2-phenyl-octahydro-1,3,8,10-tetraoxa-anthracen-7-yl)-heptane-1,2-diol (181489-41-8)

Guidance literature:

Multi-step reaction with 10 steps

1: 60 percent / (COCl)2, DMSO / CH₂Cl₂ / -78 °C

2: tetrahydrofuran / -78 °C

3: Et₃SiH, BF₃*Et₂O / CH₂Cl₂ / -20 °C

4: 1.) catecholborane, (PPh₃)RhCl, 2.) 30percent aq. H₂O₂, 3 N aq. NaOH / 1.) THF, 23 deg C, 2.) 23 deg C

5: 80 percent / CrO₃, H₂SO₄

6: 85 percent / H₂ / Pd(OH)2/C / methanol / 23 °C

7: 90 percent / p-TsOH / dimethylformamide / 50 °C

8: 95 percent / CSA / benzene / 80 °C

9: 1.) n-BuLi, 2.) Et₃SiH, BF₃*Et₂O, 3.) Ph₃SnH, BEt₃, 4.) NIS, 5.) n-BuLi

10: OsO₄, NMO / H₂O; acetone; 2-methyl-propan-2-ol / 23 °C

With chromium(VI) oxide; triethylsilane; sodium hydroxide; N-iodo-succinimide; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; oxalyl dichloride; triethyl borane; (PPh₃)RhCl; sulfuric acid; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; triphenylstannane; hydrogen; dihydrogen peroxide; toluene-4-sulfonic acid; dimethyl sulfoxide; benzo[1,3,2]dioxaborole; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; benzene;

DOI:10.1021/ja961230+

upstream raw materials:

tert-Butyl-[(E)-(3R,4S)-3,4-dimethyl-7-((2R,4aR,7R,8aR,9aS,10aS)-2-phenyl-octahydro-1,3,8,10-tetraoxa-anthracen-7-yl)-hept-6-enyloxy]-diphenyl-silane

(2R,3S,4S,5R,6S)-3,5-Bis-benzyloxy-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-4-ol

2,4,6-tri-O-benzyl-3-deoxy-α-D-methylglucopyranoside

(3R,4S)-3,4-Dimethyl-hexane-1,6-diol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 181489-41-8 (1S,2R,4S,5R)-7-(tert-Butyl-diphenyl-silanyloxy)-4,5-dimethyl-1-((2R,4aR,7R,8aR,9aS,10aS)-2-phenyl-octahydro-1,3,8,10-tetraoxa-anthracen-7-yl)-heptane-1,2-diol

Send

Send

Metric Ton KG G Pound L ML

Send

Send