tert-butyl (2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methylcarbamate

Base Information

Chemical Name:tert-butyl (2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methylcarbamate
CAS No.:1421471-99-9
Molecular Formula:C₁₈H₁₇ClF₄N₂O₂
Molecular Weight:404.792
Hs Code.:

Synonyms:tert-butyl (2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methylcarbamate

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Chemical Property of tert-butyl (2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methylcarbamate

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Technology Process of tert-butyl (2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methylcarbamate

There total 5 articles about tert-butyl (2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 935520-41-5
2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)nicotinonitrile

: 24424-99-5
di-tert-butyl dicarbonate

: 1421471-99-9
tert-butyl (2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methylcarbamate

Guidance literature:: 2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)nicotinonitrile; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 5 ℃; for 20h; Inert atmosphere; Reflux;

di-tert-butyl dicarbonate; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 935520-61-9
(2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methanamine

: 24424-99-5
di-tert-butyl dicarbonate

: 1421471-99-9
tert-butyl (2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methylcarbamate

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 116548-04-0
2-hydroxy-6-(trifluoromethyl)nicotinonitrile

: 1421471-99-9
tert-butyl (2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 4 h / 100 °C / Inert atmosphere

3: dimethylsulfide borane complex / tetrahydrofuran / 20 h / 0 - 5 °C / Reflux; Inert atmosphere

4: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide borane complex; sodium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; toluene;