N-((2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyridin-2-yl)acetamide

Base Information

Chemical Name:N-((2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyridin-2-yl)acetamide
CAS No.:1421471-91-1
Molecular Formula:C₂₀H₁₄ClF₄N₃O
Molecular Weight:423.797
Hs Code.:

Synonyms:N-((2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyridin-2-yl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyridin-2-yl)acetamide

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Technology Process of N-((2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyridin-2-yl)acetamide

There total 6 articles about N-((2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyridin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 13115-43-0
2-pyridineacetic acid

: 1421472-01-6
(2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methanamine hydrochloride

: 1421471-91-1
N-((2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyridin-2-yl)acetamide

Guidance literature:: With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; for 24h;

Reference yield:

: 116548-04-0
2-hydroxy-6-(trifluoromethyl)nicotinonitrile

: 1421471-91-1
N-((2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyridin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 4 h / 100 °C / Inert atmosphere

3: dimethylsulfide borane complex / tetrahydrofuran / 20 h / 0 - 5 °C / Reflux; Inert atmosphere

4: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

5: hydrogenchloride / 1,4-dioxane / 12 h / Cooling

6: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 24 h

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide borane complex; sodium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;

Reference yield:

: 1421471-94-4
3-cyano-6-(trifluoromethyl)pyridin-2-yl trifluoromethanesulfonate

: 1421471-91-1
N-((2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyridin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 4 h / 100 °C / Inert atmosphere

2: dimethylsulfide borane complex / tetrahydrofuran / 20 h / 0 - 5 °C / Reflux; Inert atmosphere

3: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane / 12 h / Cooling

5: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 24 h

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide borane complex; sodium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; water; toluene;