(E)-4-[(2R,3S,4S,6S)-4-Benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-2-methyl-but-2-enoic acid ethyl ester

Base Information

Chemical Name:(E)-4-[(2R,3S,4S,6S)-4-Benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-2-methyl-but-2-enoic acid ethyl ester
CAS No.:147806-45-9
Molecular Formula:C₃₃H₄₈O₆Si
Molecular Weight:568.826
Hs Code.:

Synonyms:(E)-4-[(2R,3S,4S,6S)-4-Benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-2-methyl-but-2-enoic acid ethyl ester

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Chemical Property of (E)-4-[(2R,3S,4S,6S)-4-Benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-2-methyl-but-2-enoic acid ethyl ester

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Technology Process of (E)-4-[(2R,3S,4S,6S)-4-Benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-2-methyl-but-2-enoic acid ethyl ester

There total 9 articles about (E)-4-[(2R,3S,4S,6S)-4-Benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-2-methyl-but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 147806-45-9
(E)-4-[(2R,3S,4S,6S)-4-Benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-2-methyl-but-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

2: 1.) O₃, 2.) Ph₃P / 1.) CH₂Cl₂, -78 deg C, 10 min, 2.) CH₂Cl₂, 25 deg C, 1 h

3: benzene / 2 h / 80 °C

With 2,6-dimethylpyridine; ozone; triphenylphosphine; In dichloromethane; benzene;

Reference yield:

: 100-39-0
benzyl bromide

: 147806-45-9
(E)-4-[(2R,3S,4S,6S)-4-Benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-2-methyl-but-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / NaH, n-Bu₄NI / tetrahydrofuran / 24 h / 25 °C

2: 98 percent / TFA / toluene / 0.25 h / 0 °C

3: 1.) Bu₂SnO, 2.) CsF / 1.) MeOH, 60 deg C, 1.5 h, 2.) DMF, 25 deg C, 16 h

4: 82 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

5: 1.) O₃, 2.) Ph₃P / 1.) CH₂Cl₂, -78 deg C, 10 min, 2.) CH₂Cl₂, 25 deg C, 1 h

6: benzene / 2 h / 80 °C

With 2,6-dimethylpyridine; tetra-(n-butyl)ammonium iodide; sodium hydride; di(n-butyl)tin oxide; ozone; triphenylphosphine; cesium fluoride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene; benzene;

Reference yield:

: 132375-56-5
((3aR,4R,6S,7aS)-4-Allyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl)-methanol

: 147806-45-9
(E)-4-[(2R,3S,4S,6S)-4-Benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-2-methyl-but-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / NaH, n-Bu₄NI / tetrahydrofuran / 24 h / 25 °C

2: 98 percent / TFA / toluene / 0.25 h / 0 °C

3: 1.) Bu₂SnO, 2.) CsF / 1.) MeOH, 60 deg C, 1.5 h, 2.) DMF, 25 deg C, 16 h

4: 82 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

5: 1.) O₃, 2.) Ph₃P / 1.) CH₂Cl₂, -78 deg C, 10 min, 2.) CH₂Cl₂, 25 deg C, 1 h

6: benzene / 2 h / 80 °C

With 2,6-dimethylpyridine; tetra-(n-butyl)ammonium iodide; sodium hydride; di(n-butyl)tin oxide; ozone; triphenylphosphine; cesium fluoride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene; benzene;