ethyl 2-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl)acetate

Base Information

• Chemical Name: ethyl 2-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl)acetate
• CAS No.: 1174044-30-4
• Molecular Formula: C₁₇H₂₂FNO₄
• Molecular Weight: 323.364
• Mol file: 1174044-30-4.mol

Synonyms:ethyl 2-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl)acetate

Chemical Property of ethyl 2-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl)acetate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 2-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl)acetate

There total 1 articles about ethyl 2-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(2-fluoro-5-iodophenyl)(4-methoxypiperidin-1-yl)methanone (1174044-29-1) + diethyl malonate (105-53-3) → ethyl 2-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl)acetate (1174044-30-4)

Guidance literature:

With caesium carbonate; 2-Phenylphenol; copper(l) iodide; In tetrahydrofuran; at 25 - 160 ℃; for 1.5h; Microwave irradiation;

Reference yield: 85.0%

ethyl 2-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl)acetate (1174044-30-4) → 2-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl)acetic acid (1174044-31-5)

Guidance literature:

ethyl 2-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl)acetate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

With hydrogenchloride; water;

upstream raw materials:

(2-fluoro-5-iodophenyl)(4-methoxypiperidin-1-yl)methanone

diethyl malonate

Downstream raw materials:

2-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl)acetic acid