Technology Process of 5-(benzyloxy)-1-bromo-2,3-dimethoxybenzene
There total 1 articles about 5-(benzyloxy)-1-bromo-2,3-dimethoxybenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 23 ℃;
for 20h;
Inert atmosphere;
DOI:10.1021/ol2017005
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / diethyl ether / 1 h / -78 °C / Inert atmosphere
1.2: 16 h / -78 - 23 °C / Inert atmosphere
2.1: n-butyllithium / diethyl ether / 5 h / 0 °C / Inert atmosphere
2.2: 0.5 h / 23 °C / Inert atmosphere
2.3: 1 h / 23 °C / Inert atmosphere
3.1: 5%-palladium/activated carbon; hydrogen / methanol / 16 h / 23 °C / 760.05 Torr
4.1: copper(l) chloride; (-)-sparteine / methanol; dichloromethane / 48 h / 23 °C / Resolution of racemate; Inert atmosphere
5.1: triethylamine / tetrahydrofuran / 2 h / 23 °C / Inert atmosphere
With
n-butyllithium; 5%-palladium/activated carbon; hydrogen; triethylamine; copper(l) chloride; (-)-sparteine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/ol2017005
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / diethyl ether / 1 h / -78 °C / Inert atmosphere
1.2: 16 h / -78 - 23 °C / Inert atmosphere
2.1: n-butyllithium / diethyl ether / 5 h / 0 °C / Inert atmosphere
2.2: 0.5 h / 23 °C / Inert atmosphere
2.3: 1 h / 23 °C / Inert atmosphere
3.1: 5%-palladium/activated carbon; hydrogen / methanol / 16 h / 23 °C / 760.05 Torr
4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 24 h / 0 °C / Inert atmosphere
With
dmap; n-butyllithium; 5%-palladium/activated carbon; hydrogen; dicyclohexyl-carbodiimide;
In
methanol; diethyl ether; dichloromethane;
DOI:10.1021/ol2017005
