(2S,3S)-3-(tert-butyldiphenylsilyloxy)-2-methylbutanal oxime

Base Information

Chemical Name:(2S,3S)-3-(tert-butyldiphenylsilyloxy)-2-methylbutanal oxime
CAS No.:1132969-93-7
Molecular Formula:C₂₁H₂₉NO₂Si
Molecular Weight:355.552
Hs Code.:

Synonyms:(2S,3S)-3-(tert-butyldiphenylsilyloxy)-2-methylbutanal oxime

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Chemical Property of (2S,3S)-3-(tert-butyldiphenylsilyloxy)-2-methylbutanal oxime

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Technology Process of (2S,3S)-3-(tert-butyldiphenylsilyloxy)-2-methylbutanal oxime

There total 5 articles about (2S,3S)-3-(tert-butyldiphenylsilyloxy)-2-methylbutanal oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1239498-96-4
(2R,3S)-3-(tert-butyldiphenylsilyloxy)-2-methylbutanal

: 1132969-93-7
(2S,3S)-3-(tert-butyldiphenylsilyloxy)-2-methylbutanal oxime

Guidance literature:: With hydroxylamine hydrochloride; In pyridine; ethanol; at 20 ℃; for 12.5h; Inert atmosphere;
DOI:10.1002/chem.201102797

Reference yield:

: 1379802-66-0
(R)-4-benzyl-3-((2R,3S)-3-(tert-butyldiphenylsilyloxy)-2-methylbutanoyl)oxazolidin-2-one

: 1132969-93-7
(2S,3S)-3-(tert-butyldiphenylsilyloxy)-2-methylbutanal oxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium borohydride / tetrahydrofuran; diethyl ether; ethanol / 4.5 h / 0 - 20 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; potassium bromide / dichloromethane / 0 °C / pH 8.6 / aq. buffer

2.2: 0.42 h / 0 °C

3.1: hydroxylamine hydrochloride / pyridine; ethanol / 12.5 h / 20 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; lithium borohydride; hydroxylamine hydrochloride; potassium bromide; In tetrahydrofuran; pyridine; diethyl ether; ethanol; dichloromethane;
DOI:10.1002/chem.201102797

Reference yield:

: 468756-88-9
(4R,2'R,3'S)-N-(3-hydroxy-2-methylbutanoyl)-4-benzyl-2-oxazolidinone

: 1132969-93-7
(2S,3S)-3-(tert-butyldiphenylsilyloxy)-2-methylbutanal oxime

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 44 h / 20 °C / Inert atmosphere

2.1: lithium borohydride / tetrahydrofuran; diethyl ether; ethanol / 4.5 h / 0 - 20 °C / Inert atmosphere

3.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; potassium bromide / dichloromethane / 0 °C / pH 8.6 / aq. buffer

3.2: 0.42 h / 0 °C

4.1: hydroxylamine hydrochloride / pyridine; ethanol / 12.5 h / 20 °C / Inert atmosphere

With 1H-imidazole; 2,2,6,6-tetramethyl-piperidine-N-oxyl; lithium borohydride; hydroxylamine hydrochloride; potassium bromide; In tetrahydrofuran; pyridine; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201102797