Technology Process of (R)-4-((1R,2R,4R,5S)-5-(tert-butyldiphenylsilyloxy)-1-hydroxy-2,4-dimethyl-3-oxohexyl)-1,3-dioxolan-2-one
There total 14 articles about (R)-4-((1R,2R,4R,5S)-5-(tert-butyldiphenylsilyloxy)-1-hydroxy-2,4-dimethyl-3-oxohexyl)-1,3-dioxolan-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; hydrogen; boric acid; nickel;
In
methanol;
at 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1002/anie.200804645
- Guidance literature:
-
With
hydrogen; boric acid;
In
methanol; water;
at 20 ℃;
for 3h;
DOI:10.1002/chem.201102797
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium borohydride / tetrahydrofuran; diethyl ether; ethanol / 4.5 h / 0 - 20 °C / Inert atmosphere
2.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; potassium bromide / dichloromethane / 0 °C / pH 8.6 / aq. buffer
2.2: 0.42 h / 0 °C
3.1: hydroxylamine hydrochloride / pyridine; ethanol / 12.5 h / 20 °C / Inert atmosphere
4.1: dichloromethane / -78 °C / Inert atmosphere
4.2: 0 - 20 °C / Inert atmosphere
5.1: toluene-4-sulfonic acid / methanol / 1.75 h / 20 °C / Inert atmosphere
6.1: pyridine / dichloromethane / 0.17 h / -78 - 0 °C / Inert atmosphere
7.1: hydrogen; boric acid / methanol; water / 3 h / 20 °C
With
pyridine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; lithium borohydride; hydroxylamine hydrochloride; hydrogen; boric acid; toluene-4-sulfonic acid; potassium bromide;
In
tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1002/chem.201102797