3,4-dichloro-N-(4-{2-[methyl-(tetrahydro-pyran-4-yl)-amino]-ethyl}-phenyl)-benzamide

Base Information

Chemical Name:3,4-dichloro-N-(4-{2-[methyl-(tetrahydro-pyran-4-yl)-amino]-ethyl}-phenyl)-benzamide
CAS No.:874888-72-9
Molecular Formula:C₂₁H₂₄Cl₂N₂O₂
Molecular Weight:407.34
Hs Code.:

Synonyms:3,4-dichloro-N-(4-{2-[methyl-(tetrahydro-pyran-4-yl)-amino]-ethyl}-phenyl)-benzamide

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Chemical Property of 3,4-dichloro-N-(4-{2-[methyl-(tetrahydro-pyran-4-yl)-amino]-ethyl}-phenyl)-benzamide

Chemical Property:

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Technology Process of 3,4-dichloro-N-(4-{2-[methyl-(tetrahydro-pyran-4-yl)-amino]-ethyl}-phenyl)-benzamide

There total 5 articles about 3,4-dichloro-N-(4-{2-[methyl-(tetrahydro-pyran-4-yl)-amino]-ethyl}-phenyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 874888-71-8
[2-(4-amino-phenyl)-ethyl]-methyl-(tetrahydro-pyran-4-yl)-amine

: 3024-72-4
3,4-dichlorobenzoyl chloride

: 874888-72-9
3,4-dichloro-N-(4-{2-[methyl-(tetrahydro-pyran-4-yl)-amino]-ethyl}-phenyl)-benzamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: 874888-72-9
3,4-dichloro-N-(4-{2-[methyl-(tetrahydro-pyran-4-yl)-amino]-ethyl}-phenyl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: NaB(OAc)3H; AcOH / CH₂Cl₂ / 6 h / 20 °C

2: NaB(OAc)3H / CH₂Cl₂; H₂O / 20 °C

3: SnCl₂*2H₂O / tetrahydrofuran

With sodium tris(acetoxy)borohydride; acetic acid; tin(ll) chloride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmcl.2007.01.115

Reference yield:

: 874888-69-4
C₁₃H₁₈N₂O₃

: 874888-72-9
3,4-dichloro-N-(4-{2-[methyl-(tetrahydro-pyran-4-yl)-amino]-ethyl}-phenyl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: NaB(OAc)3H / CH₂Cl₂; H₂O / 20 °C

2: SnCl₂*2H₂O / tetrahydrofuran

With sodium tris(acetoxy)borohydride; tin(ll) chloride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmcl.2007.01.115