(2-(2-((3-p-toluyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl)-acetyl hydrazinylidene)methylphenoxy)acetic acid

Base Information

Chemical Name:(2-(2-((3-p-toluyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl)-acetyl hydrazinylidene)methylphenoxy)acetic acid
CAS No.:380473-08-5
Molecular Formula:C₂₆H₂₂N₄O₅S
Molecular Weight:502.55
Hs Code.:

Synonyms:(2-(2-((3-p-toluyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl)-acetyl hydrazinylidene)methylphenoxy)acetic acid

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Chemical Property of (2-(2-((3-p-toluyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl)-acetyl hydrazinylidene)methylphenoxy)acetic acid

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Technology Process of (2-(2-((3-p-toluyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl)-acetyl hydrazinylidene)methylphenoxy)acetic acid

There total 7 articles about (2-(2-((3-p-toluyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl)-acetyl hydrazinylidene)methylphenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1547192-82-4
ethyl (2-(2-((3-p-toluyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl)acetylhydrazinylidene)methylphenoxy)acetate

: 380473-08-5
(2-(2-((3-p-toluyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl)-acetyl hydrazinylidene)methylphenoxy)acetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2013.12.049

Reference yield:

: 134-20-3
2-carbomethoxyaniline

: 380473-08-5
(2-(2-((3-p-toluyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl)-acetyl hydrazinylidene)methylphenoxy)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: dimethyl sulfoxide / 0.42 h / 120 °C / Microwave irradiation

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C

3: hydrazine / ethanol / 0 °C

4: sulfuric acid / ethanol / 4 h / Reflux

5: lithium hydroxide / tetrahydrofuran / 18 h / 20 °C

With sulfuric acid; potassium carbonate; lithium hydroxide; hydrazine; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.12.049

Reference yield:

: 37641-50-2
3-(4-methylphenyl)-2-thioxoquinazolin-4-one

: 380473-08-5
(2-(2-((3-p-toluyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl)-acetyl hydrazinylidene)methylphenoxy)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C

2: hydrazine / ethanol / 0 °C

3: sulfuric acid / ethanol / 4 h / Reflux

4: lithium hydroxide / tetrahydrofuran / 18 h / 20 °C

With sulfuric acid; potassium carbonate; lithium hydroxide; hydrazine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.12.049