Butylcarbamoylmethyl-[(2,2-diphenyl-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: Butylcarbamoylmethyl-[(2,2-diphenyl-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester
• CAS No.: 175354-01-5
• Molecular Formula: C₂₇H₃₇N₃O₄
• Molecular Weight: 467.608
• Mol file: 175354-01-5.mol

Synonyms:Butylcarbamoylmethyl-[(2,2-diphenyl-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester

Chemical Property of Butylcarbamoylmethyl-[(2,2-diphenyl-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Butylcarbamoylmethyl-[(2,2-diphenyl-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester

There total 2 articles about Butylcarbamoylmethyl-[(2,2-diphenyl-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,2-Diphenylethylamine (3963-62-0) + N-((tert-butyloxy)carbonyl)-N'-(n-butyl)iminodiacetic acid monoamide (175353-92-1) → Butylcarbamoylmethyl-[(2,2-diphenyl-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester (175354-01-5)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 20h;

DOI:10.1021/ja9530681

Reference yield:

N-((tert-butyloxy)carbonyl)iminodiacetic acid (56074-20-5) → Butylcarbamoylmethyl-[(2,2-diphenyl-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester (175354-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 1.) DMF, 25 deg C, 1 h, 2.) DMF, 25 deg C, 20 h

2: 99 percent / diisopropylethylamine, PyBOP / dimethylformamide / 20 h / 25 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/ja9530681

Reference yield:

Butylcarbamoylmethyl-[(2,2-diphenyl-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester (175354-01-5) → 2-(Butylcarbamoylmethyl-amino)-N-(2,2-diphenyl-ethyl)-acetamide

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 25 ℃; for 0.75h;

DOI:10.1021/ja9530681

upstream raw materials:

2,2-Diphenylethylamine

N-((tert-butyloxy)carbonyl)-N'-(n-butyl)iminodiacetic acid monoamide

N-((tert-butyloxy)carbonyl)iminodiacetic acid