5’-O-(4,4’-dimethoxytrityl)-3’-O-(t-butyldimethylsilyl)-2’-deoxy-3-[4-(dioctadecylamino)but-2-ynyl]thymidine

Base Information

Chemical Name:5’-O-(4,4’-dimethoxytrityl)-3’-O-(t-butyldimethylsilyl)-2’-deoxy-3-[4-(dioctadecylamino)but-2-ynyl]thymidine
CAS No.:1428580-38-4
Molecular Formula:C₇₇H₁₂₃N₃O₇Si
Molecular Weight:1230.93
Hs Code.:

Synonyms:5’-O-(4,4’-dimethoxytrityl)-3’-O-(t-butyldimethylsilyl)-2’-deoxy-3-[4-(dioctadecylamino)but-2-ynyl]thymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5’-O-(4,4’-dimethoxytrityl)-3’-O-(t-butyldimethylsilyl)-2’-deoxy-3-[4-(dioctadecylamino)but-2-ynyl]thymidine

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Technology Process of 5’-O-(4,4’-dimethoxytrityl)-3’-O-(t-butyldimethylsilyl)-2’-deoxy-3-[4-(dioctadecylamino)but-2-ynyl]thymidine

There total 5 articles about 5’-O-(4,4’-dimethoxytrityl)-3’-O-(t-butyldimethylsilyl)-2’-deoxy-3-[4-(dioctadecylamino)but-2-ynyl]thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1428580-29-3
N-(4-chlorobut-2-yn-1-yl)-N-octadecyloctadecan-1-amine

: 80971-33-1
5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine

: 1428580-38-4
5’-O-(4,4’-dimethoxytrityl)-3’-O-(t-butyldimethylsilyl)-2’-deoxy-3-[4-(dioctadecylamino)but-2-ynyl]thymidine

Guidance literature:: With dibenzo-18-crown-6; potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 48h; Inert atmosphere;
DOI:10.1002/hlca.201100410

Reference yield:

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 1428580-38-4
5’-O-(4,4’-dimethoxytrityl)-3’-O-(t-butyldimethylsilyl)-2’-deoxy-3-[4-(dioctadecylamino)but-2-ynyl]thymidine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 20 °C / Inert atmosphere

2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Cooling with ice; Inert atmosphere

3: potassium carbonate; dibenzo-18-crown-6 / N,N-dimethyl-formamide / 48 h / 60 °C / Inert atmosphere

With pyridine; 1H-imidazole; dibenzo-18-crown-6; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100410

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 1428580-38-4
5’-O-(4,4’-dimethoxytrityl)-3’-O-(t-butyldimethylsilyl)-2’-deoxy-3-[4-(dioctadecylamino)but-2-ynyl]thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Cooling with ice; Inert atmosphere

2: potassium carbonate; dibenzo-18-crown-6 / N,N-dimethyl-formamide / 48 h / 60 °C / Inert atmosphere

With 1H-imidazole; dibenzo-18-crown-6; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100410