5-[3-(2-Methyl-2H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

Base Information

Chemical Name:5-[3-(2-Methyl-2H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione
CAS No.:1239578-76-7
Molecular Formula:C₂₁H₁₆N₆O₂
Molecular Weight:384.397
Hs Code.:

Synonyms:5-[3-(2-Methyl-2H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

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Chemical Property of 5-[3-(2-Methyl-2H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

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Technology Process of 5-[3-(2-Methyl-2H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

There total 7 articles about 5-[3-(2-Methyl-2H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 5-[3-(1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione potassium salt

: 74-88-4
methyl iodide

: 1239578-76-7
5-[3-(2-Methyl-2H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

: 1239578-77-8
5-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

Guidance literature:: In dimethyl sulfoxide; at 20 ℃; for 64h;

Reference yield:

: 606-57-5
1-nitro-2-naphthylamine

: 1239578-76-7
5-[3-(2-Methyl-2H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

: 1239578-77-8
5-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 16 h / 110 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 4 h / 20 °C

3: toluene / 0.5 h / 80 - 110 °C / Cooling with ice

4: azido tributyltin (IV) / N,N-dimethyl-formamide; toluene / 16 h / 110 °C

5: potassium hydrogencarbonate / ethanol; water

6: dimethyl sulfoxide / 64 h / 20 °C

With hydrogen; potassium hydrogencarbonate; caesium carbonate; azido tributyltin (IV); tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 6952-59-6
3-cyanobromobenzene

: 1239578-76-7
5-[3-(2-Methyl-2H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

: 1239578-77-8
5-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 16 h / 110 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 4 h / 20 °C

3: toluene / 0.5 h / 80 - 110 °C / Cooling with ice

4: azido tributyltin (IV) / N,N-dimethyl-formamide; toluene / 16 h / 110 °C

5: potassium hydrogencarbonate / ethanol; water

6: dimethyl sulfoxide / 64 h / 20 °C

With hydrogen; potassium hydrogencarbonate; caesium carbonate; azido tributyltin (IV); tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;