5-isopropoxy-6-methoxy-3-methyl-2-[(1R)-1-phenylethyl]-1,2,3,4-tetrahdyroisoquinoline

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Chemical Name:5-isopropoxy-6-methoxy-3-methyl-2-[(1R)-1-phenylethyl]-1,2,3,4-tetrahdyroisoquinoline
CAS No.:825633-48-5
Molecular Formula:C₂₂H₂₉NO₂
Molecular Weight:339.478
Hs Code.:

Synonyms:5-isopropoxy-6-methoxy-3-methyl-2-[(1R)-1-phenylethyl]-1,2,3,4-tetrahdyroisoquinoline

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Chemical Property of 5-isopropoxy-6-methoxy-3-methyl-2-[(1R)-1-phenylethyl]-1,2,3,4-tetrahdyroisoquinoline

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Technology Process of 5-isopropoxy-6-methoxy-3-methyl-2-[(1R)-1-phenylethyl]-1,2,3,4-tetrahdyroisoquinoline

There total 2 articles about 5-isopropoxy-6-methoxy-3-methyl-2-[(1R)-1-phenylethyl]-1,2,3,4-tetrahdyroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 825633-47-4
(1R)-N-[(2-allyl-3-isopropoxy-4-methoxyphenyl)methyl]-(1-phenylethyl)amine

: 825633-48-5
5-isopropoxy-6-methoxy-3-methyl-2-[(1R)-1-phenylethyl]-1,2,3,4-tetrahdyroisoquinoline

Guidance literature:: (1R)-N-[(2-allyl-3-isopropoxy-4-methoxyphenyl)methyl]-(1-phenylethyl)amine; With mercury(II) diacetate; In tetrahydrofuran; water; at 20 ℃; for 24h;

With sodium hydroxide; sodium tetrahydroborate; In tetrahydrofuran; water; at 20 ℃; for 24h; Further stages.;
DOI:10.1002/ejoc.200700580

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 825633-48-5
5-isopropoxy-6-methoxy-3-methyl-2-[(1R)-1-phenylethyl]-1,2,3,4-tetrahdyroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: p-toluenesulfonic acid / toluene / 18 h / Heating

1.2: 89 percent / NaBH₄; H₂O / methanol / 18 h / 0 - 20 °C

2.1: 75 percent / n-butyllithium / 24 h / 20 - 60 °C

With n-butyllithium; toluene-4-sulfonic acid; In toluene;
DOI:10.1016/j.tetlet.2004.10.155