N-[9-(3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-tetrahydro-furan-2-yl)-2-(2-phenoxy-acetylamino)-9H-purin-6-yl]-2-phenoxy-acetamide

Base Information

Chemical Name:N-[9-(3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-tetrahydro-furan-2-yl)-2-(2-phenoxy-acetylamino)-9H-purin-6-yl]-2-phenoxy-acetamide
CAS No.:256485-53-7
Molecular Formula:C₅₂H₅₇N₇O₈Si
Molecular Weight:936.152
Hs Code.:

<i>N</i>-[9-(3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-tetrahydro-furan-2-yl)-2-(2-phenoxy-acetylamino)-9<i>H</i>-purin-6-yl]-2-phenoxy-acetamide

Synonyms:N-[9-(3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-tetrahydro-furan-2-yl)-2-(2-phenoxy-acetylamino)-9H-purin-6-yl]-2-phenoxy-acetamide

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Chemical Property of N-[9-(3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-tetrahydro-furan-2-yl)-2-(2-phenoxy-acetylamino)-9H-purin-6-yl]-2-phenoxy-acetamide

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Technology Process of N-[9-(3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-tetrahydro-furan-2-yl)-2-(2-phenoxy-acetylamino)-9H-purin-6-yl]-2-phenoxy-acetamide

There total 11 articles about N-[9-(3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-tetrahydro-furan-2-yl)-2-(2-phenoxy-acetylamino)-9H-purin-6-yl]-2-phenoxy-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.5%

: C₃₂H₃₉N₉O₇Si

: 14470-28-1
mono-4-methoxytrityl chloride

: 256485-53-7
N-[9-(3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-tetrahydro-furan-2-yl)-2-(2-phenoxy-acetylamino)-9H-purin-6-yl]-2-phenoxy-acetamide

Guidance literature:: C₃₂H₃₉N₉O₇Si; With palladium 10% on activated carbon; hydrogen; In pyridine; for 2h;

mono-4-methoxytrityl chloride; With pyridine; at 20 ℃; Molecular sieve;

Reference yield:

: 256485-54-8
4-Methoxy-benzoic acid (2S,3R,4R,5R)-5-[2,6-bis-(2-phenoxy-acetylamino)-purin-9-yl]-4-(tert-butyl-dimethyl-silanyloxy)-3-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-tetrahydro-furan-2-ylmethyl ester

: 256485-53-7
N-[9-(3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-tetrahydro-furan-2-yl)-2-(2-phenoxy-acetylamino)-9H-purin-6-yl]-2-phenoxy-acetamide

Guidance literature:: With sodium hydroxide; In pyridine; methanol; water; at 0 ℃; for 0.0833333h;
DOI:10.1080/15257770008045446

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 256485-53-7
N-[9-(3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-tetrahydro-furan-2-yl)-2-(2-phenoxy-acetylamino)-9H-purin-6-yl]-2-phenoxy-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / pyridine / 15 h / 20 °C

2: 0.96 g / N-methylimidazole / pyridine / 60 h / 40 °C

3: 0.5 g / NaOH / pyridine; methanol; H₂O / 0.08 h / 0 °C

With 1H-imidazole; 1-methyl-1H-imidazole; sodium hydroxide; In pyridine; methanol; water;
DOI:10.1080/15257770008045446