1-(3,5-dimethylpyrazol-1-yl)-3-(phenyl-2-oxoethylsulfanyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

Base Information

Chemical Name:1-(3,5-dimethylpyrazol-1-yl)-3-(phenyl-2-oxoethylsulfanyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS No.:1269793-01-2
Molecular Formula:C₂₃H₂₂N₄OS
Molecular Weight:402.52
Hs Code.:

Synonyms:1-(3,5-dimethylpyrazol-1-yl)-3-(phenyl-2-oxoethylsulfanyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

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Chemical Property of 1-(3,5-dimethylpyrazol-1-yl)-3-(phenyl-2-oxoethylsulfanyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

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Technology Process of 1-(3,5-dimethylpyrazol-1-yl)-3-(phenyl-2-oxoethylsulfanyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

There total 3 articles about 1-(3,5-dimethylpyrazol-1-yl)-3-(phenyl-2-oxoethylsulfanyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1269792-66-6
1-(3,5-dimethylpyrazol-1-yl)-3-sulfanyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

: 70-11-1
α-bromoacetophenone

: 1269793-01-2
1-(3,5-dimethylpyrazol-1-yl)-3-(phenyl-2-oxoethylsulfanyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

Guidance literature:: With sodium acetate; In ethanol; for 2h; Reflux;
DOI:10.1016/j.ejmech.2010.11.036

Reference yield:

: 50706-78-0
2,3,5,6,7,8-hexahydro-1-morpholin-4-yl-3-thioxo-isoquinoline-4-carbonitrile

: 1269793-01-2
1-(3,5-dimethylpyrazol-1-yl)-3-(phenyl-2-oxoethylsulfanyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 2 h / Reflux

2: ethanol / 1 h / Reflux

3: sodium acetate / ethanol / 2 h / Reflux

With sodium acetate; hydrazine hydrate; In ethanol;
DOI:10.1016/j.ejmech.2010.11.036

Reference yield:

: 1269792-60-0
1-hydrazino-3-thioxo-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

: 1269793-01-2
1-(3,5-dimethylpyrazol-1-yl)-3-(phenyl-2-oxoethylsulfanyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 1 h / Reflux

2: sodium acetate / ethanol / 2 h / Reflux

With sodium acetate; In ethanol;
DOI:10.1016/j.ejmech.2010.11.036