(1S,2S)-2-[(tert-butyldiphenylsiloxy)methyl]-1-(formylmethyl)cyclopropane

Base Information

Chemical Name:(1S,2S)-2-[(tert-butyldiphenylsiloxy)methyl]-1-(formylmethyl)cyclopropane
CAS No.:1046470-60-3
Molecular Formula:C₂₂H₂₈O₂Si
Molecular Weight:352.549
Hs Code.:

Synonyms:(1S,2S)-2-[(tert-butyldiphenylsiloxy)methyl]-1-(formylmethyl)cyclopropane

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Chemical Property of (1S,2S)-2-[(tert-butyldiphenylsiloxy)methyl]-1-(formylmethyl)cyclopropane

Chemical Property:

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Technology Process of (1S,2S)-2-[(tert-butyldiphenylsiloxy)methyl]-1-(formylmethyl)cyclopropane

There total 3 articles about (1S,2S)-2-[(tert-butyldiphenylsiloxy)methyl]-1-(formylmethyl)cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₃₀O₂Si

: 1046470-60-3
(1S,2S)-2-[(tert-butyldiphenylsiloxy)methyl]-1-(formylmethyl)cyclopropane

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃; for 0.333333h;
DOI:10.1021/ol8013304

Reference yield:

: 251444-03-8
(1R,2S)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane

: 1046470-60-3
(1S,2S)-2-[(tert-butyldiphenylsiloxy)methyl]-1-(formylmethyl)cyclopropane

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

1.2: 5 h / 0 °C / Inert atmosphere

2.1: hydrogenchloride / water; acetone / 0 h / 0 °C

With hydrogenchloride; sodium hexamethyldisilazane; In tetrahydrofuran; water; acetone; 1.2: Wittig reaction;
DOI:10.1039/c1ob06496g

Reference yield:

: 1046470-60-3
(1S,2S)-2-[(tert-butyldiphenylsiloxy)methyl]-1-(formylmethyl)cyclopropane

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.5h;

With triethylamine; In dichloromethane; at -78 - 20 ℃; for 1.5h;