(E)-1-methyl-2-oxo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)spiro[indoline-3,4'-piperidine]-5-carbonitrile

Base Information

Chemical Name:(E)-1-methyl-2-oxo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)spiro[indoline-3,4'-piperidine]-5-carbonitrile
CAS No.:1185754-14-6
Molecular Formula:C₂₄H₂₀F₃N₃O₂
Molecular Weight:439.437
Hs Code.:

Synonyms:(E)-1-methyl-2-oxo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)spiro[indoline-3,4'-piperidine]-5-carbonitrile

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Chemical Property of (E)-1-methyl-2-oxo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)spiro[indoline-3,4'-piperidine]-5-carbonitrile

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Technology Process of (E)-1-methyl-2-oxo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)spiro[indoline-3,4'-piperidine]-5-carbonitrile

There total 7 articles about (E)-1-methyl-2-oxo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)spiro[indoline-3,4'-piperidine]-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 1185754-09-9
(E)-1-methyl-2-oxo-1'-(3-(2-(trifiuoromethyl)phenyl)acryloyl)spiro[indoline-3,4'-piperidine]-5-carboxamide

: 1185754-14-6
(E)-1-methyl-2-oxo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)spiro[indoline-3,4'-piperidine]-5-carbonitrile

Guidance literature:: With pyridine; trifluoroacetic anhydride; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 1184729-07-4
methyl 2-oxospiro[indoline-3,4'-piperidine]-5-carboxylate hydrochloride

: 1185754-14-6
(E)-1-methyl-2-oxo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)spiro[indoline-3,4'-piperidine]-5-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 2 h / 20 °C

3.1: water; lithium hydroxide / methanol / 8 h / 20 °C

4.1: ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

5.1: pyridine; trifluoroacetic anhydride / 1,4-dioxane / 20 °C

With pyridine; ammonia; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 946135-52-0
1'-(tert-butoxycarbonyl)-2-oxospiro[indoline-3,4'-piperidine]-5-carboxylic acid

: 1185754-14-6
(E)-1-methyl-2-oxo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)spiro[indoline-3,4'-piperidine]-5-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 0 - 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

3.2: 2 h / 20 °C

4.1: water; lithium hydroxide / methanol / 8 h / 20 °C

5.1: ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

6.1: pyridine; trifluoroacetic anhydride / 1,4-dioxane / 20 °C

With pyridine; thionyl chloride; ammonia; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;