Namodenoson

Base Information

Chemical Name:Namodenoson
CAS No.:132206-99-6
Molecular Formula:C₂₁H₂₀N₄
Molecular Weight:328.417
Hs Code.:
European Community (EC) Number:634-077-2
UNII:Z07JR07J6C
DSSTox Substance ID:DTXSID80167504
Nikkaji Number:J626.443C
Wikidata:Q27076097
NCI Thesaurus Code:C79826
Pharos Ligand ID:VH8X4CVMP3A8
Metabolomics Workbench ID:153783
ChEMBL ID:CHEMBL431733

Synonyms:2-chloro-N(6)-(3-iodobenzyl)-9-(5-(methylcarbamoyl)-beta-D-ribofuranosyl)adenine;2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide;2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide;2-Cl-IB-MECA;C-IBzA-MU;CF102 compound

Suppliers and Price of Namodenoson

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Namodenoson

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:544.01228
Heavy Atom Count:30
Complexity:623

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CNC(=O)C1C(C(C(O1)N2C=NC3=C(N=C(N=C32)Cl)NCC4=CC(=CC=C4)I)O)O
Isomeric SMILES:CNC(=O)[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=C(N=C32)Cl)NCC4=CC(=CC=C4)I)O)O
Recent ClinicalTrials:Namodenoson in the Treatment of Advanced Hepatocellular Carcinoma in Patients With Child-Pugh Class B7 Cirrhosis
Recent EU Clinical Trials:A Phase 2B Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Namodenoson in the Treatment of Non-Alcoholic Steatohepatitis (NASH)

Technology Process of Namodenoson

There total 8 articles about Namodenoson which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39061-97-7
4-chloro-3-nitroquinoline

: 132206-99-6
N-phenyl-2-cyclopentyl-1H-imidazo[4,5-c]quinolin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / NH₃

2: 98 percent / H₂ / Pd

3: 81 percent / polyphosphoric acid / 5 h / 100 °C

4: 95 percent / 3-chloroperoxybenzoic acid / CHCl₃; CH₂Cl₂; methanol / 0.5 h / Heating

5: 75 percent / POCl₃ / toluene; dimethylformamide / 0.67 h / 20 - 100 °C

6: 15 percent / ethanol / 0.67 h / 120 °C / microwave irradiation

With PPA; ammonia; hydrogen; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; palladium; In methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm060086s

Reference yield:

: 42606-33-7
3-nitro-4-aminoquinoline

: 132206-99-6
N-phenyl-2-cyclopentyl-1H-imidazo[4,5-c]quinolin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / H₂ / Pd

2: 81 percent / polyphosphoric acid / 5 h / 100 °C

3: 95 percent / 3-chloroperoxybenzoic acid / CHCl₃; CH₂Cl₂; methanol / 0.5 h / Heating

4: 75 percent / POCl₃ / toluene; dimethylformamide / 0.67 h / 20 - 100 °C

5: 15 percent / ethanol / 0.67 h / 120 °C / microwave irradiation

With PPA; hydrogen; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; palladium; In methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm060086s

Reference yield:

: 50332-66-6
3-nitro-quinolin-4-ol

: 132206-99-6
N-phenyl-2-cyclopentyl-1H-imidazo[4,5-c]quinolin-4-amine

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / POCl₃

2: 95 percent / NH₃

3: 98 percent / H₂ / Pd

4: 81 percent / polyphosphoric acid / 5 h / 100 °C

5: 95 percent / 3-chloroperoxybenzoic acid / CHCl₃; CH₂Cl₂; methanol / 0.5 h / Heating

6: 75 percent / POCl₃ / toluene; dimethylformamide / 0.67 h / 20 - 100 °C

7: 15 percent / ethanol / 0.67 h / 120 °C / microwave irradiation

With PPA; ammonia; hydrogen; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; palladium; In methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm060086s