42606-33-7Relevant articles and documents
Condensed Heterocycles; Part XII. Synthesis of Thiadiazoloquinolines and Selenadiazoloquinolines
Sharma, K.S.,Singh, Ram Phul,Kumari, Sharda
, p. 581 (1983)
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Vicarious nucleophilic amination of nitroquinolines by 1,1,1- trimethylhydrazinium iodide
Grzegozek, Maria
experimental part, p. 1879 - 1882 (2009/06/18)
(Chemical Equation Presented) The amination of 3-, 5-, 6-, 7- and 8-nitroquinoline via the vicarious nucleophilic substitution of hydrogen (VNS) with 1,1,1-trimethylhydrazinium iodide (TMHI) in the presence of t-BuOK in DMSO was studied. The amination occurs regioselectively giving ortho or ortho and para isomers relative to the nitro group with a high yield (95-86%). 2-Nitroquinoline does not undergo vicarious amination but displacement of the labile nitro group by an amino group occurs and then transformation to an imine compound and hydrolysis gives 2(1H)-quinolinone.
A3 ADENOSINE RECEPTOR ALLOSTERIC MODULATORS
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Page/Page column 21, (2008/06/13)
The present invention relates to allosteric modulation of A3 adenosine receptor (A3AR) and provides for the use of an A3 adenosine receptor modulator (A3RM),for the preparation of pharmaceutical compositions for