N-(3-fluoro-benzylidene)-N'-(7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine

Base Information

• Chemical Name: N-(3-fluoro-benzylidene)-N'-(7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine
• CAS No.: 1232222-68-2
• Molecular Formula: C₂₂H₂₀FN₇O
• Molecular Weight: 417.446
• Mol file: 1232222-68-2.mol

Synonyms:N-(3-fluoro-benzylidene)-N'-(7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine

Chemical Property of N-(3-fluoro-benzylidene)-N'-(7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-fluoro-benzylidene)-N'-(7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine

There total 4 articles about N-(3-fluoro-benzylidene)-N'-(7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

5-chloro-7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine (1232224-69-9) + 3-Fluorobenzaldehyde (456-48-4) → N-(3-fluoro-benzylidene)-N'-(7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine (1232222-68-2)

Guidance literature:

acetic acid; In ethanol; at 1 - 30 ℃; for 1h;

Reference yield:

isonicotinic acid ethylester (1570-45-2) → N-(3-fluoro-benzylidene)-N'-(7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine (1232222-68-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium tert-butylate / 18-crown-6 ether / tetrahydrofuran / 0.08 h / 60 °C

1.2: 0.5 h

1.3: 20 h / 30 °C / Cooling with ice

2.1: sodium ethanolate / ethanol / 9 h / Reflux

2.2: 4 h / Cooling with ice; Reflux

3.1: 1,4-dioxane / 1 h / 1 - 30 °C

4.1: acetic acid / ethanol / 1 h / 1 - 30 °C

With potassium tert-butylate; sodium ethanolate; 18-crown-6 ether; acetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol;

Reference yield:

5-pyridin-4-yl-2H-pyrazol-3-yl-amine (91912-53-7) → N-(3-fluoro-benzylidene)-N'-(7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine (1232222-68-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium ethanolate / ethanol / 9 h / Reflux

1.2: 4 h / Cooling with ice; Reflux

2.1: 1,4-dioxane / 1 h / 1 - 30 °C

3.1: acetic acid / ethanol / 1 h / 1 - 30 °C

With sodium ethanolate; acetic acid; In 1,4-dioxane; ethanol;

upstream raw materials:

5-chloro-7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine

3-Fluorobenzaldehyde

isonicotinic acid ethylester

5-pyridin-4-yl-2H-pyrazol-3-yl-amine