Technology Process of (3aS,8S,8aS,8bR)-8-Methyl-2-phenyl-4,6,7,8,8a,8b-hexahydro-3aH-cyclopenta[e]isoindole-1,3-dione
There total 4 articles about (3aS,8S,8aS,8bR)-8-Methyl-2-phenyl-4,6,7,8,8a,8b-hexahydro-3aH-cyclopenta[e]isoindole-1,3-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 72 percent / oxalyl chloride, DMSO, TEA / CH2Cl2 / -78 °C
2: 50 percent / n-butyllithium, methyltriphenylphosphonium bromide / diethyl ether / 24 h / Ambient temperature
3: toluene / 18 h / Ambient temperature
With
n-butyllithium; oxalyl dichloride; TEA; Methyltriphenylphosphonium bromide; dimethyl sulfoxide;
In
diethyl ether; dichloromethane; toluene;
DOI:10.1021/ja00222a022
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 78 percent / diisobutylaluminum hydride, NaF, H2O / diethyl ether / 0.5 h / 0 °C
2: 72 percent / oxalyl chloride, DMSO, TEA / CH2Cl2 / -78 °C
3: 50 percent / n-butyllithium, methyltriphenylphosphonium bromide / diethyl ether / 24 h / Ambient temperature
4: toluene / 18 h / Ambient temperature
With
n-butyllithium; oxalyl dichloride; TEA; water; Methyltriphenylphosphonium bromide; diisobutylaluminium hydride; sodium fluoride; dimethyl sulfoxide;
In
diethyl ether; dichloromethane; toluene;
DOI:10.1021/ja00222a022
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 50 percent / n-butyllithium, methyltriphenylphosphonium bromide / diethyl ether / 24 h / Ambient temperature
2: toluene / 18 h / Ambient temperature
With
n-butyllithium; Methyltriphenylphosphonium bromide;
In
diethyl ether; toluene;
DOI:10.1021/ja00222a022
