(E)-2,6-di(1H-pyrazol-1-yl)-4-(4-cyanostyryl)pyridine

Base Information

• Chemical Name: (E)-2,6-di(1H-pyrazol-1-yl)-4-(4-cyanostyryl)pyridine
• CAS No.: 1373317-02-2
• Molecular Formula: C₂₀H₁₄N₆
• Molecular Weight: 338.371
• Mol file: 1373317-02-2.mol

Synonyms:(E)-2,6-di(1H-pyrazol-1-yl)-4-(4-cyanostyryl)pyridine

Chemical Property of (E)-2,6-di(1H-pyrazol-1-yl)-4-(4-cyanostyryl)pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of (E)-2,6-di(1H-pyrazol-1-yl)-4-(4-cyanostyryl)pyridine

There total 2 articles about (E)-2,6-di(1H-pyrazol-1-yl)-4-(4-cyanostyryl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2,6-di(1H-pyrazol-1-yl)isonicotinaldehyde + diethyl [(4-cyanophenyl)methyl]phosphonate (1552-41-6) → (Z)-2,6-di(1H-pyrazol-1-yl)-4-(4-cyanostyryl)pyridine (1373317-01-1) + (E)-2,6-di(1H-pyrazol-1-yl)-4-(4-cyanostyryl)pyridine (1373317-02-2)

Guidance literature:

diethyl [(4-cyanophenyl)methyl]phosphonate; With n-butyllithium; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

2,6-di(1H-pyrazol-1-yl)isonicotinaldehyde; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ic300030b

Reference yield: 50.0%

2,6-di(1H-pyrazol-1-yl)isonicotinaldehyde + 4-cyanobenzyltris(2-(methoxymethoxy)phenyl)phosphonium bromide (1373317-07-7) → (Z)-2,6-di(1H-pyrazol-1-yl)-4-(4-cyanostyryl)pyridine (1373317-01-1) + (E)-2,6-di(1H-pyrazol-1-yl)-4-(4-cyanostyryl)pyridine (1373317-02-2)

Guidance literature:

4-cyanobenzyltris(2-(methoxymethoxy)phenyl)phosphonium bromide; With n-butyllithium; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

2,6-di(1H-pyrazol-1-yl)isonicotinaldehyde; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ic300030b

Reference yield: 92.0%

iron(II) tetrafluoroborate hexahydrate + (E)-2,6-di(1H-pyrazol-1-yl)-4-(4-cyanostyryl)pyridine (1373317-02-2) → [Fe((E)-2,6-di(1H-pyrazol-1-yl)-4-(4-cyanostyryl)pyridine)2](BF4)2*2.5H2O

Guidance literature:

In acetone; (N2) to soln. ligand in acetone soln. Fe(BF4)2*6H2O in acetone was added, stirred at room temp. for 30 min; ppt. was filtered off, washed with ice-cold acetone and Et2O, recrystd. from MeNO2-Et2O and dried in vacuo at 100°C; elem. anal.;

DOI:10.1021/ic300030b

upstream raw materials:

4-cyanobenzyltris(2-(methoxymethoxy)phenyl)phosphonium bromide

diethyl [(4-cyanophenyl)methyl]phosphonate