2-(4-(4-cycohexyl-3-methylisoxazol-5-yl)phenyl)-1,1,1-trifluoropropan-2-ol

Base Information

Chemical Name:2-(4-(4-cycohexyl-3-methylisoxazol-5-yl)phenyl)-1,1,1-trifluoropropan-2-ol
CAS No.:1093853-75-8
Molecular Formula:C₁₉H₂₂F₃NO₂
Molecular Weight:353.384
Hs Code.:

Synonyms:2-(4-(4-cycohexyl-3-methylisoxazol-5-yl)phenyl)-1,1,1-trifluoropropan-2-ol

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Chemical Property of 2-(4-(4-cycohexyl-3-methylisoxazol-5-yl)phenyl)-1,1,1-trifluoropropan-2-ol

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Technology Process of 2-(4-(4-cycohexyl-3-methylisoxazol-5-yl)phenyl)-1,1,1-trifluoropropan-2-ol

There total 6 articles about 2-(4-(4-cycohexyl-3-methylisoxazol-5-yl)phenyl)-1,1,1-trifluoropropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093853-85-0
C₁₈H₂₁NO₂

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 1093853-75-8
2-(4-(4-cycohexyl-3-methylisoxazol-5-yl)phenyl)-1,1,1-trifluoropropan-2-ol

Guidance literature:: C₁₈H₂₁NO₂; (trifluoromethyl)trimethylsilane; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h;

With water; sodium hydrogencarbonate; In tetrahydrofuran;

Reference yield:

: 3609-53-8
methyl 4-acetylbenzoate

: 1093853-75-8
2-(4-(4-cycohexyl-3-methylisoxazol-5-yl)phenyl)-1,1,1-trifluoropropan-2-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene-4-sulfonic acid / benzene / 3 h / Heating / reflux

2.1: isopropylmagnesium chloride / tetrahydrofuran / 2.3 h / -10 - 20 °C

3.1: iodine; magnesium / tetrahydrofuran / 2 h / 20 °C

3.2: 2 h / 20 °C

4.1: sodium ethanolate / 16 h / 20 °C

5.1: tetrahydrofuran; diethyl ether / 0.5 h / 0 - 23 °C

6.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 0 °C

7.1: pyridine; hydroxylamine hydrochloride / 19 h / 80 °C

8.1: hydrogenchloride / tetrahydrofuran; water / 4 h

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

With pyridine; hydrogenchloride; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; iodine; isopropylmagnesium chloride; sodium ethanolate; sodium hydrogencarbonate; Dess-Martin periodane; magnesium; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water; benzene; 6.1: Dess-Martin Oxidation;

Reference yield:

: 1093853-73-6
C₁₃H₁₇NO₄

: 1093853-75-8
2-(4-(4-cycohexyl-3-methylisoxazol-5-yl)phenyl)-1,1,1-trifluoropropan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: iodine; magnesium / tetrahydrofuran / 2 h / 20 °C

1.2: 2 h / 20 °C

2.1: sodium ethanolate / 16 h / 20 °C

3.1: tetrahydrofuran; diethyl ether / 0.5 h / 0 - 23 °C

4.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 0 °C

5.1: pyridine; hydroxylamine hydrochloride / 19 h / 80 °C

6.1: hydrogenchloride / tetrahydrofuran; water / 4 h

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

With pyridine; hydrogenchloride; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; iodine; sodium ethanolate; sodium hydrogencarbonate; Dess-Martin periodane; magnesium; In tetrahydrofuran; diethyl ether; dichloromethane; water; 4.1: Dess-Martin Oxidation;