(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester

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Chemical Name:(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester
CAS No.:178861-39-7
Molecular Formula:C₂₉H₄₆N₂O₈
Molecular Weight:550.693
Hs Code.:

Synonyms:(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester

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Chemical Property of (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester

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Technology Process of (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester

There total 14 articles about (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 60008-24-4
Boc-L-Ala-L-Hmb-OH

: L-Amp-O-tBu hydrochloride

: 178861-39-7
(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide;
DOI:10.1039/CC9960001139

Reference yield:

: 15761-38-3
L-N-Boc-Ala

: 178861-39-7
(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / DCC, DMAP

2: 99 percent / H₂ / 10percent Pd/C

3: 99 percent / DCC, HOBT, NMM

With 4-methyl-morpholine; dmap; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal;
DOI:10.1039/CC9960001139

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 178861-39-7
(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-(4-methoxy-phenyl)-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / Et₃N

2: 93 percent / DCC, DMAP

3: 99 percent / H₂ / 10percent Pd/C

4: 99 percent / DCC, HOBT, NMM

With 4-methyl-morpholine; dmap; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal;
DOI:10.1039/CC9960001139