(E)-2-(3,3-diisopropyltriaz-1-enyl)-3-(trifluoromethyl)benzonitrile

Base Information

• Chemical Name: (E)-2-(3,3-diisopropyltriaz-1-enyl)-3-(trifluoromethyl)benzonitrile
• CAS No.: 1052092-62-2
• Molecular Formula: C₁₄H₁₇F₃N₄
• Molecular Weight: 298.311
• Mol file: 1052092-62-2.mol

Synonyms:(E)-2-(3,3-diisopropyltriaz-1-enyl)-3-(trifluoromethyl)benzonitrile

Chemical Property of (E)-2-(3,3-diisopropyltriaz-1-enyl)-3-(trifluoromethyl)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(3,3-diisopropyltriaz-1-enyl)-3-(trifluoromethyl)benzonitrile

There total 1 articles about (E)-2-(3,3-diisopropyltriaz-1-enyl)-3-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-amino-3-trifluoromethylbenzonitrile (58458-14-3) + diisopropylamine (108-18-9) → (E)-2-(3,3-diisopropyltriaz-1-enyl)-3-(trifluoromethyl)benzonitrile (1052092-62-2)

Guidance literature:

2-amino-3-trifluoromethylbenzonitrile; With tert.-butylnitrite; boron trifluoride diethyl etherate; In tetrahydrofuran; diethyl ether; at -20 - 0 ℃; for 2.08333h; Inert atmosphere;

diisopropylamine; With pyridine; In acetonitrile; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.200800154

Reference yield: 95.0%

(E)-2-(3,3-diisopropyltriaz-1-enyl)-3-(trifluoromethyl)benzonitrile (1052092-62-2) + phenyllithium (591-51-5) → (E)-[2-(3,3-diisopropyltriaz-1-enyl)-3-(trifluoromethyl)phenyl](phenyl)methanimine (1052092-89-3)

Guidance literature:

In tetrahydrofuran; dibutyl ether; at 20 ℃; for 2.5h; Inert atmosphere;

DOI:10.1002/ejoc.200800154

Reference yield: 80.0%

n-butyllithium (109-72-8,29786-93-4) + (E)-2-(3,3-diisopropyltriaz-1-enyl)-3-(trifluoromethyl)benzonitrile (1052092-62-2) → (E)-1-[2-(3,3-diisopropyltriaz-1-enyl)-3-(trifluoromethyl)phenyl]pentan-1-imine (1052092-87-1)

Guidance literature:

In tetrahydrofuran; hexane; at 20 ℃; for 2.5h; Inert atmosphere;

DOI:10.1002/ejoc.200800154

upstream raw materials:

2-amino-3-trifluoromethylbenzonitrile

diisopropylamine

Downstream raw materials:

(E)-[2-(3,3-diisopropyltriaz-1-enyl)-3-(trifluoromethyl)phenyl]methanamine

(E)-1-[2-(3,3-diisopropyltriaz-1-enyl)-3-(trifluoromethyl)phenyl]pentan-1-imine

(E)-N-(1-{2-[(E)-3,3-diisopropyltriaz-1-enyl]-3-(trifluoromethyl)phenyl}ethylidene)-2-methylpropane-2-sulfinamide

(E)-1-[2-(3,3-diisopropyltriaz-1-enyl)-3-(trifluoromethyl)phenyl]ethanone