N⁴-<4-<(2,3-dimethoxybenzoyl)amino>butyryl>-N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine

Base Information

• Chemical Name: N⁴-<4-<(2,3-dimethoxybenzoyl)amino>butyryl>-N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine
• CAS No.: 78217-88-6
• Molecular Formula: C₃₈H₅₀N₄O₁₀
• Molecular Weight: 722.836

Synonyms:N⁴-<4-<(2,3-dimethoxybenzoyl)amino>butyryl>-N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine

Chemical Property of N⁴-<4-<(2,3-dimethoxybenzoyl)amino>butyryl>-N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine

Chemical Property:

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Technology Process of N⁴-<4-<(2,3-dimethoxybenzoyl)amino>butyryl>-N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine

There total 5 articles about N⁴-<4-<(2,3-dimethoxybenzoyl)amino>butyryl>-N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N1,N8-Bis(2,3-bis(methyloxy)benzoyl)spermidine (78217-75-1) + 4-<(2,3-dimethoxybenzoyl)amino>butyric acid (78217-85-3) → N4-<4-<(2,3-dimethoxybenzoyl)amino>butyryl>-N1,N8-bis(2,3-dimethoxybenzoyl)spermidine (78217-88-6)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; for 48h;

DOI:10.1021/jo00335a041

Reference yield:

N-(2-Cyanoethyl)-N-(3-cyanopropyl)-benzylamine (1216-04-2) → N4-<4-<(2,3-dimethoxybenzoyl)amino>butyryl>-N1,N8-bis(2,3-dimethoxybenzoyl)spermidine (78217-88-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 63 percent / LiAlH₄, AlCl₃

2: 98 percent / triethylamine / CH₂Cl₂ / 18 h / 0 deg C to room temperature

3: 98 percent / 1) H₂, 2) NaOMe / 1) PdCl₂ / 1) glacial acetic acid, room temperature, 2) MeOH, 30 min

4: 80 percent / dicyclohexylcarbodiimide, NEt₃ / CH₂Cl₂ / 48 h

With lithium aluminium tetrahydride; aluminium trichloride; hydrogen; sodium methylate; triethylamine; dicyclohexyl-carbodiimide; palladium dichloride; In dichloromethane;

DOI:10.1021/jo00335a041

Reference yield:

N-(3-aminobutyl)-N-(3-aminopropyl)(phenylmethyl)amine (73038-05-8) → N4-<4-<(2,3-dimethoxybenzoyl)amino>butyryl>-N1,N8-bis(2,3-dimethoxybenzoyl)spermidine (78217-88-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / triethylamine / CH₂Cl₂ / 18 h / 0 deg C to room temperature

2: 98 percent / 1) H₂, 2) NaOMe / 1) PdCl₂ / 1) glacial acetic acid, room temperature, 2) MeOH, 30 min

3: 80 percent / dicyclohexylcarbodiimide, NEt₃ / CH₂Cl₂ / 48 h

With hydrogen; sodium methylate; triethylamine; dicyclohexyl-carbodiimide; palladium dichloride; In dichloromethane;

DOI:10.1021/jo00335a041

upstream raw materials:

N¹,N⁸-Bis(2,3-bis(methyloxy)benzoyl)spermidine

4-<(2,3-dimethoxybenzoyl)amino>butyric acid

2,3-dimethoxybenzoic acid

N-(2-Cyanoethyl)-N-(3-cyanopropyl)-benzylamine

Downstream raw materials:

N⁴-<4-<(2,3-dihydroxybenzoyl)amino>butyryl>-N¹,N⁸-bis(2,3-dihydroxybenzoyl)spermidine

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