O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> S-(4-chlorobenzyl) N,N-diisopropylphosphorothioamidite

Base Information

• Chemical Name: O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> S-(4-chlorobenzyl) N,N-diisopropylphosphorothioamidite
• CAS No.: 120047-04-3
• Molecular Formula: C₄₄H₅₁ClN₃O₇PS
• Molecular Weight: 832.398
• Mol file: 120047-04-3.mol

Synonyms:O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> S-(4-chlorobenzyl) N,N-diisopropylphosphorothioamidite

Chemical Property of O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> S-(4-chlorobenzyl) N,N-diisopropylphosphorothioamidite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> S-(4-chlorobenzyl) N,N-diisopropylphosphorothioamidite

There total 3 articles about O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> S-(4-chlorobenzyl) N,N-diisopropylphosphorothioamidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

S-(4-chlorobenzyl) N,N,N',N'-tetraisopropylphosphorothiodiamidite (120047-01-0) + 5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> S-(4-chlorobenzyl) N,N-diisopropylphosphorothioamidite (120047-04-3)

Guidance literature:

With 1H-tetrazole; In dichloromethane; acetonitrile; Ambient temperature;

Reference yield:

bis(diisopropylamino)chlorophosphine (56183-63-2) → O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> S-(4-chlorobenzyl) N,N-diisopropylphosphorothioamidite (120047-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) 4 h, room temperature, 2.) 2 h

2: tetrazole / acetonitrile / 8 h / Ambient temperature

With sodium hydride; 1H-tetrazole; In acetonitrile;

DOI:10.1016/S0040-4039(00)80801-1

Reference yield:

(4-chlorophenyl)methanethiol (6258-66-8) → O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> S-(4-chlorobenzyl) N,N-diisopropylphosphorothioamidite (120047-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) 4 h, room temperature, 2.) 2 h

2: tetrazole / acetonitrile / 8 h / Ambient temperature

With sodium hydride; 1H-tetrazole; In acetonitrile;

DOI:10.1016/S0040-4039(00)80801-1

upstream raw materials:

S-(4-chlorobenzyl) N,N,N',N'-tetraisopropylphosphorothiodiamidite

5'-O-(4-4'-dimethoxytrityl)thymidine

bis(diisopropylamino)chlorophosphine

(4-chlorophenyl)methanethiol

Downstream raw materials:

O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> S-(4-chlorobenzyl) O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate

5'-O-dimethoxytritylthymidine S-(4-cholorobenzyl)-3'-O-(5'-O-N₂-isobutyryldeoxyguanosinyl)-phosphorodithioate

C₆₁H₇₂ClN₉O₁₃P₂S₂

C₄₈H₅₀ClN₄O₁₂PS₂