5-bromo-4-isopropoxy-2-(4-tosylpiperazin-1-yl)pyrimidine

Base Information

• Chemical Name: 5-bromo-4-isopropoxy-2-(4-tosylpiperazin-1-yl)pyrimidine
• CAS No.: 1427688-91-2
• Molecular Formula: C₁₈H₂₃BrN₄O₃S
• Molecular Weight: 455.376
• Mol file: 1427688-91-2.mol

Synonyms:5-bromo-4-isopropoxy-2-(4-tosylpiperazin-1-yl)pyrimidine

Chemical Property of 5-bromo-4-isopropoxy-2-(4-tosylpiperazin-1-yl)pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-bromo-4-isopropoxy-2-(4-tosylpiperazin-1-yl)pyrimidine

There total 1 articles about 5-bromo-4-isopropoxy-2-(4-tosylpiperazin-1-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-tosylpiperazine (27106-51-0) + C7H8BrClN2O (1289215-25-3) → 5-bromo-4-isopropoxy-2-(4-tosylpiperazin-1-yl)pyrimidine (1427688-91-2)

Guidance literature:

In tetrahydrofuran; isopropyl alcohol; at 60 ℃; for 3h; Inert atmosphere;

DOI:10.1002/ejoc.201200989

Reference yield: 85.0%

5-bromo-4-isopropoxy-2-(4-tosylpiperazin-1-yl)pyrimidine (1427688-91-2) + tri-n-butyl(vinyl)tin (7486-35-3) → 4-isopropoxy-2-(4-tosylpiperazin-1-yl)-5-vinylpyrimidine (1427688-92-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 60 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201200989

Reference yield:

5-bromo-4-isopropoxy-2-(4-tosylpiperazin-1-yl)pyrimidine (1427688-91-2) → [4-Oipr-5-(4,5-dihydroIMES)Cl2Ru=CH]pyrimidin-2-yl-4-tosylpiperidine

Guidance literature:

Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 60 °C / Inert atmosphere

2: copper(l) chloride / dichloromethane / 1 h / 25 - 40 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; copper(l) chloride; In 1,4-dioxane; dichloromethane; water; 1: |Stille Cross Coupling;

DOI:10.1002/ejoc.201200989

upstream raw materials:

1-tosylpiperazine

C₇H₈BrClN₂O

Downstream raw materials:

4-isopropoxy-2-(4-tosylpiperazin-1-yl)-5-vinylpyrimidine