27106-51-0

Basic information

• Product Name: 1-(TOLUENE-4-SULFONYL)-PIPERAZINE
• Synonyms: BUTTPARK 80\07-76;ART-CHEM-BB B003964;CHEMBRDG-BB 3003964;IFLAB-BB F1174-2442;1-(TOLUENE-4-SULFONYL)-PIPERAZINE;1-[(4-METHYLPHENYL)SULFONYL]PIPERAZINE;AKOS MSC-0754;AKOS B003964
• CAS NO: 27106-51-0
• Molecular Formula: C₁₁H₁₆N₂O₂S
• Molecular Weight: 240.32
• Mol File: 27106-51-0.mol
• Article Data: 29

Chemical Properties

• Melting Point: 97-100°C
• Boiling Point: 387.4°Cat760mmHg
• Flash Point: 188.1°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 3.31E-06mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 7.90±0.10(Predicted)
• CAS DataBase Reference: 1-(TOLUENE-4-SULFONYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(TOLUENE-4-SULFONYL)-PIPERAZINE(27106-51-0)
• EPA Substance Registry System: 1-(TOLUENE-4-SULFONYL)-PIPERAZINE(27106-51-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 27106-51-0(Hazardous Substances Data)

Usage

General Description

1-(Toluene-4-sulfonyl)-piperazine is a chemical compound that consists of a piperazine molecule with a toluene-4-sulfonyl group attached to it. It is often used as a reagent in organic synthesis and pharmaceutical research. 1-(TOLUENE-4-SULFONYL)-PIPERAZINE has been found to have potential applications in drug development, particularly in the design of antipsychotic and antidepressant medications. Additionally, 1-(toluene-4-sulfonyl)-piperazine has been reported to possess insecticidal properties, making it a candidate for agricultural and pest control applications. Its unique structure and reactivity make it a valuable building block for the synthesis of complex organic molecules and could hold promise for a variety of applications in the pharmaceutical and agricultural industries.

InChI:InChI=1/C11H16N2O2S/c1-10-2-4-11(5-3-10)16(14,15)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3

Upstream product

• 110-85-0 piperazine 
• 1153-45-3 4-nitrophenyl 4-methylbenzenesulfonate 
• 98-59-9 p-toluenesulfonyl chloride 
• 284039-54-9 1-vinyloxycarbonylpiperazine 
• 742-25-6 2,4-dinitrophenyl 4-methylbenzenesulfonate 
• 2232-08-8 N-tosylimidazole 
• 142-64-3 piperazine dihydrochloride 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 250331-04-5 tert-butyl 4-tosylpiperazine-1-carboxylate 

Downstream Products

• 53727-44-9 1-chloro-2-[4-(4-methylphenylsulfonyl)piperazin-1-yl]ethane 
• 1061767-97-2 2-chloro-6,7-dimethoxy-4-(4-tosylpiperazin-1-yl)quinazoline monohydrochloride 
• 892495-38-4 2-[4-(4-methylbenzenesulfonyl)-1-piperazinomethyl]-3,5,6-trimethylpyrazine 
• 1196448-95-9 5-nitro-7-((4-tosylpiperazin-1-yl)methyl)quinolin-8-ol 
• 1264533-98-3 2-bromo-4-(4-tosylpiperazin-1-yl) quinazoline 
• 1309868-69-6 2-chloro-4-(4-tosylpiperazin-1-yl)pyrimidine 
• 1309868-72-1 3-chloro-1-(4-tosylpiperazin-1-yl)isoquinoline 
• 1309868-70-9 2-chloro-4,5-dimethyl-6-(4-tosylpiperazin-1-yl)pyrimidine 
• 1264534-31-7 2-chloro-4-(4-tosylpiperazin-1-yl)quinazoline 
• 1309868-68-5 2-chloro-4-(4-tosylpiperazin-1-yl)pyrido[3,2-d]pyrimidine 
• 1309868-67-4 2-chloro-4-(4-tosylpiperazin-1-yl)pyrido[2,3-d]pyrimidine 
• 1264535-74-1 5-(4-(4-tosylpiperazin-1-yl)quinazolin-2-yl)thiazole 
• 1264535-91-2 2-(pyrimidin-5-yl)-4-(4-tosylpiperazin-1-yl)quinazoline 
• 1264534-04-4 4-(4-tosylpiperazin-1-yl)quinazoline-2-carbonitrile 

Relevant articles and documents

Constructing the 2-(thiobenzyl)ethyl carbamate linker via thiyl radical addition

N-Vinyloxycarbonyl derivatives of secondary amines undergo efficient addition of thiyl radical and, using Merrifield SH resin, this reaction provides a new entry to resin-bound 2-(thiobenzyl)ethyl carbamates. (C) 2000 Elsevier Science Ltd.

Discovery of Novel Chromone Derivatives Containing a Sulfonamide Moiety as Anti-ToCV Agents through the Tomato Chlorosis Virus Coat Protein-Oriented Screening Method

A number of novel chromone derivatives containing sulfonamide moieties were designed and synthesized, and the activity of compounds against tomato chlorosis virus (ToCV) was assessed using the ToCVCP-oriented screening method. Comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) models were established based on the dissociation constant (Kd) values of the target compounds, and compound 35 was designed and synthesized with the aid of CoMFA and CoMSIA models. The study of affinity interaction indicated that compound 35 exhibited excellent affinity with ToCVCP with a Kd value of 0.11 μM, which was better than that of the positive control agents xiangcaoliusuobingmi (0.44 μM) and ningnanmycin (0.79 μM). In addition, the in vivo inhibitory effect of compound 35 on the ToCVCP gene was evaluated by the quantitative real-time polymerase chain reaction. ToCVCP gene expression levels of the compound 35 treatment group were reduced by 67.2%, which was better than that of the positive control agent ningnanmycin (59.5%). Therefore, compound 35 can be used as a potential anti-ToCV drug in the future.

Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosis

8-Nitrobenzothiazinones (BTZs) are a promising class of antimycobacterial agents currently under investigation in clinical trials. Starting from thiourea derivatives, a new synthetic pathway to BTZs was established. It allows the formation of the thiazinone ring system in one synthetic step and is applicable for preparation of a wide variety of BTZ analogues. The synthetic procedure furthermore facilitates the replacement of the sulphur atom in the thiazinone ring system by oxygen or nitrogen to afford the analogous benzoxazinone and quinazolinone systems. 36 BTZ analogues were prepared and tested in luminescence-based assays for in vitro activity against Mycobacterium tuberculosis (Mtb) using the microdilution broth method and a high-throughput macrophage infection assay.