(2S)-tert-butyl 2-(2-amino-4-(2-(4-amino-3-((S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxamido)phenyl)-3-(4-(benzyloxy)phenyl)cyclopropyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

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Chemical Name:(2S)-tert-butyl 2-(2-amino-4-(2-(4-amino-3-((S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxamido)phenyl)-3-(4-(benzyloxy)phenyl)cyclopropyl)phenylcarbamoyl)pyrrolidine-1-carboxylate
CAS No.:1382650-12-5
Molecular Formula:C₄₈H₅₈N₆O₇
Molecular Weight:831.025
Hs Code.:

(2S)-tert-butyl 2-(2-amino-4-(2-(4-amino-3-((S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxamido)phenyl)-3-(4-(benzyloxy)phenyl)cyclopropyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

Synonyms:(2S)-tert-butyl 2-(2-amino-4-(2-(4-amino-3-((S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxamido)phenyl)-3-(4-(benzyloxy)phenyl)cyclopropyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

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Chemical Property of (2S)-tert-butyl 2-(2-amino-4-(2-(4-amino-3-((S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxamido)phenyl)-3-(4-(benzyloxy)phenyl)cyclopropyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S)-tert-butyl 2-(2-amino-4-(2-(4-amino-3-((S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxamido)phenyl)-3-(4-(benzyloxy)phenyl)cyclopropyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

There total 8 articles about (2S)-tert-butyl 2-(2-amino-4-(2-(4-amino-3-((S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxamido)phenyl)-3-(4-(benzyloxy)phenyl)cyclopropyl)phenylcarbamoyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1382250-18-1
4,4'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)dibenzene-1,2-diamine

: (2S,2'S)-tert-butyl 2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(2-amino-5,1-phenylene))bis(azanediyl)bis(oxomethylene)dipyrrolidine-1-carboxylate

: 1382650-12-5
(2S)-tert-butyl 2-(2-amino-4-(2-(4-amino-3-((S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxamido)phenyl)-3-(4-(benzyloxy)phenyl)cyclopropyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dimethyl sulfoxide; at 20 ℃; for 2h;

Reference yield:

: 471239-60-8
di-tert-butyl (4-bromobenzene-1,2-diyl)biscarbamate

: 1382650-12-5
(2S)-tert-butyl 2-(2-amino-4-(2-(4-amino-3-((S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxamido)phenyl)-3-(4-(benzyloxy)phenyl)cyclopropyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; tetrahydrofuran / 18 h / 80 °C / Inert atmosphere; Microwave irradiation; sealed tube

2: boron trifluoride diethyl etherate / dichloromethane; toluene / 1 h / -25 °C

3: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / dimethyl sulfoxide / 2 h / 20 °C

With hydrogenchloride; potassium phosphate; boron trifluoride diethyl etherate; N-ethyl-N,N-diisopropylamine; HATU; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; toluene;

Reference yield:

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1382650-12-5
(2S)-tert-butyl 2-(2-amino-4-(2-(4-amino-3-((S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxamido)phenyl)-3-(4-(benzyloxy)phenyl)cyclopropyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 72 h / Inert atmosphere

2: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; tetrahydrofuran / 18 h / 80 °C / Inert atmosphere; Microwave irradiation; sealed tube

3: boron trifluoride diethyl etherate / dichloromethane; toluene / 1 h / -25 °C

4: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / dimethyl sulfoxide / 2 h / 20 °C

With hydrogenchloride; potassium phosphate; boron trifluoride diethyl etherate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; toluene;