(2S,2'S)-tert-butyl 2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))dipyrrolidine-1-carboxylate

Base Information

Chemical Name:(2S,2'S)-tert-butyl 2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))dipyrrolidine-1-carboxylate
CAS No.:1382650-15-8
Molecular Formula:C₄₈H₅₄N₆O₅
Molecular Weight:794.994
Hs Code.:

Synonyms:(2S,2'S)-tert-butyl 2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))dipyrrolidine-1-carboxylate

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Chemical Property of (2S,2'S)-tert-butyl 2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))dipyrrolidine-1-carboxylate

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Technology Process of (2S,2'S)-tert-butyl 2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))dipyrrolidine-1-carboxylate

There total 9 articles about (2S,2'S)-tert-butyl 2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))dipyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: (2S,2'S)-tert-butyl 2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(2-amino-5,1-phenylene))bis(azanediyl)bis(oxomethylene)dipyrrolidine-1-carboxylate

: 1382650-12-5
(2S)-tert-butyl 2-(2-amino-4-(2-(4-amino-3-((S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxamido)phenyl)-3-(4-(benzyloxy)phenyl)cyclopropyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

: 1382650-15-8
(2S,2'S)-tert-butyl 2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))dipyrrolidine-1-carboxylate

Guidance literature:: With acetic acid; In tetrahydrofuran; toluene; at 70 ℃; for 1h;

Reference yield:

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1382650-15-8
(2S,2'S)-tert-butyl 2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))dipyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 72 h / Inert atmosphere

2: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; tetrahydrofuran / 18 h / 80 °C / Inert atmosphere; Microwave irradiation; sealed tube

3: boron trifluoride diethyl etherate / dichloromethane; toluene / 1 h / -25 °C

4: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / dimethyl sulfoxide / 2 h / 20 °C

6: acetic acid / toluene; tetrahydrofuran / 1 h / 70 °C

With hydrogenchloride; potassium phosphate; boron trifluoride diethyl etherate; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; toluene;

Reference yield:

: 471239-60-8
di-tert-butyl (4-bromobenzene-1,2-diyl)biscarbamate

: 1382650-15-8
(2S,2'S)-tert-butyl 2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))dipyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; tetrahydrofuran / 18 h / 80 °C / Inert atmosphere; Microwave irradiation; sealed tube

2: boron trifluoride diethyl etherate / dichloromethane; toluene / 1 h / -25 °C

3: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / dimethyl sulfoxide / 2 h / 20 °C

5: acetic acid / toluene; tetrahydrofuran / 1 h / 70 °C

With hydrogenchloride; potassium phosphate; boron trifluoride diethyl etherate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; toluene;