5'-chloro-1-(5-chloro-2-fluorobenzyl)-2H,5H-spiro[imidazolidine-4,3'-indole]-2,2',5(1'H)-trione

Base Information

Chemical Name:5'-chloro-1-(5-chloro-2-fluorobenzyl)-2H,5H-spiro[imidazolidine-4,3'-indole]-2,2',5(1'H)-trione
CAS No.:916047-81-9
Molecular Formula:C₁₇H₁₀Cl₂FN₃O₃
Molecular Weight:394.189
Hs Code.:

Synonyms:5'-chloro-1-(5-chloro-2-fluorobenzyl)-2H,5H-spiro[imidazolidine-4,3'-indole]-2,2',5(1'H)-trione

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Chemical Property of 5'-chloro-1-(5-chloro-2-fluorobenzyl)-2H,5H-spiro[imidazolidine-4,3'-indole]-2,2',5(1'H)-trione

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Technology Process of 5'-chloro-1-(5-chloro-2-fluorobenzyl)-2H,5H-spiro[imidazolidine-4,3'-indole]-2,2',5(1'H)-trione

There total 1 articles about 5'-chloro-1-(5-chloro-2-fluorobenzyl)-2H,5H-spiro[imidazolidine-4,3'-indole]-2,2',5(1'H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 93210-31-2
5'-chloro-2H,5H-spiro[imidazolidine-4,3'-indole]-2,2',5(1H)-trione

: 71916-91-1
5-chloro-2-fluorobenzyl bromide

: 916047-81-9
5'-chloro-1-(5-chloro-2-fluorobenzyl)-2H,5H-spiro[imidazolidine-4,3'-indole]-2,2',5(1'H)-trione

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 ℃; for 1.5h;

Reference yield: 12.0%

: 916047-81-9
5'-chloro-1-(5-chloro-2-fluorobenzyl)-2H,5H-spiro[imidazolidine-4,3'-indole]-2,2',5(1'H)-trione

: 5292-43-3
bromoacetic acid tert-butyl ester

: 916047-82-0
tert-butyl [5'-chloro-1-(5-chloro-2-fluorobenzyl)-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetate

Guidance literature:: 5'-chloro-1-(5-chloro-2-fluorobenzyl)-2H,5H-spiro[imidazolidine-4,3'-indole]-2,2',5(1'H)-trione; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

bromoacetic acid tert-butyl ester; In N,N-dimethyl-formamide; at 0 - 20 ℃; Product distribution / selectivity;