tert-butyl [5'-chloro-1-(5-chloro-2-fluorobenzyl)-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetate

Base Information

Chemical Name:tert-butyl [5'-chloro-1-(5-chloro-2-fluorobenzyl)-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetate
CAS No.:916047-82-0
Molecular Formula:C₂₃H₂₀Cl₂FN₃O₅
Molecular Weight:508.333
Hs Code.:

Synonyms:tert-butyl [5'-chloro-1-(5-chloro-2-fluorobenzyl)-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetate

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Chemical Property of tert-butyl [5'-chloro-1-(5-chloro-2-fluorobenzyl)-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetate

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Technology Process of tert-butyl [5'-chloro-1-(5-chloro-2-fluorobenzyl)-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetate

There total 5 articles about tert-butyl [5'-chloro-1-(5-chloro-2-fluorobenzyl)-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 916048-13-0
tert-butyl 2-(5'-chloro-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl)acetate

: 71916-91-1
5-chloro-2-fluorobenzyl bromide

: 916047-82-0
tert-butyl [5'-chloro-1-(5-chloro-2-fluorobenzyl)-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetate

Guidance literature:: tert-butyl 2-(5'-chloro-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl)acetate; With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.25h;

5-chloro-2-fluorobenzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield: 12.0%

: 916047-81-9
5'-chloro-1-(5-chloro-2-fluorobenzyl)-2H,5H-spiro[imidazolidine-4,3'-indole]-2,2',5(1'H)-trione

: 5292-43-3
bromoacetic acid tert-butyl ester

: 916047-82-0
tert-butyl [5'-chloro-1-(5-chloro-2-fluorobenzyl)-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetate

Guidance literature:: 5'-chloro-1-(5-chloro-2-fluorobenzyl)-2H,5H-spiro[imidazolidine-4,3'-indole]-2,2',5(1'H)-trione; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

bromoacetic acid tert-butyl ester; In N,N-dimethyl-formamide; at 0 - 20 ℃; Product distribution / selectivity;

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 916047-82-0
tert-butyl [5'-chloro-1-(5-chloro-2-fluorobenzyl)-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2.25 h / 0 °C

1.2: 20 - 30 °C

2.1: water / ethanol / 1.5 h / Reflux

2.2: 1 h / 0 - 5 °C / pH 5

3.1: potassium carbonate / N,N-dimethyl-formamide / 2.25 h / 0 - 20 °C

3.2: 1 h / 20 °C

With water; potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ml2001196