(S)-3-(2,3-Dihydro-1H-indol-3-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid phenyl ester

Base Information

• Chemical Name: (S)-3-(2,3-Dihydro-1H-indol-3-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid phenyl ester
• CAS No.: 210702-51-5
• Molecular Formula: C₂₀H₁₉Cl₃N₂O₄
• Molecular Weight: 457.741

Synonyms:(S)-3-(2,3-Dihydro-1H-indol-3-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid phenyl ester

Chemical Property of (S)-3-(2,3-Dihydro-1H-indol-3-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid phenyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (S)-3-(2,3-Dihydro-1H-indol-3-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid phenyl ester

There total 3 articles about (S)-3-(2,3-Dihydro-1H-indol-3-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(S)-3-(1H-Indol-3-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid phenyl ester (210702-43-5) → (S)-3-(2,3-Dihydro-1H-indol-3-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid phenyl ester (210702-51-5)

Guidance literature:

With borane-THF; trifluoroacetic acid;

DOI:10.1021/ja9809408

Reference yield:

Troc-Trp-OH (88050-14-0) → (S)-3-(2,3-Dihydro-1H-indol-3-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid phenyl ester (210702-51-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / DCC, DMAP

2: 81 percent / BH₃*THF, TFA

With dmap; borane-THF; dicyclohexyl-carbodiimide; trifluoroacetic acid;

DOI:10.1021/ja9809408

Reference yield:

phenol (108-95-2,27073-41-2) → (S)-3-(2,3-Dihydro-1H-indol-3-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid phenyl ester (210702-51-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / DCC, DMAP

2: 81 percent / BH₃*THF, TFA

With dmap; borane-THF; dicyclohexyl-carbodiimide; trifluoroacetic acid;

DOI:10.1021/ja9809408

upstream raw materials:

(S)-3-(1H-Indol-3-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid phenyl ester

Troc-Trp-OH

phenol

Downstream raw materials:

(S)-3-[1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-2,3-dihydro-1H-indol-3-yl]-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid phenyl ester

(2S,9S,9aR)-9-((7S,7aS)-5,13-Dioxo-5,6,7,7a,8,13-hexahydro-6,8,13a-triaza-benzo[3,4]cyclohepta[1,2-b]naphthalen-7-ylmethyl)-9-hydroxy-2-isobutyl-3-oxo-2,3,9,9a-tetrahydro-imidazo[1,2-a]indole-1-carboxylic acid benzyl ester

(S)-2-Isobutyl-3-oxo-9-{(S)-2-phenoxycarbonyl-2-[2-(2,2,2-trichloro-ethoxycarbonylamino)-benzoylamino]-ethyl}-2,3-dihydro-imidazo[1,2-a]indole-1-carboxylic acid benzyl ester

(S)-9-[(S)-1-(2-Azido-benzoyl)-2,5-dioxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-2-isobutyl-3-oxo-2,3-dihydro-imidazo[1,2-a]indole-1-carboxylic acid benzyl ester

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