(4S,5R)-5-[(chloro-diphenyl)methyl]-N,N,2,2-tetramethyl-α,α-diphenyl-1,3-dioxolane-4-methanamin

Base Information

Chemical Name:(4S,5R)-5-[(chloro-diphenyl)methyl]-N,N,2,2-tetramethyl-α,α-diphenyl-1,3-dioxolane-4-methanamin
CAS No.:193892-73-8
Molecular Formula:C₃₃H₃₄ClNO₂
Molecular Weight:512.091
Hs Code.:

Synonyms:(4S,5R)-5-[(chloro-diphenyl)methyl]-N,N,2,2-tetramethyl-α,α-diphenyl-1,3-dioxolane-4-methanamin

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Chemical Property of (4S,5R)-5-[(chloro-diphenyl)methyl]-N,N,2,2-tetramethyl-α,α-diphenyl-1,3-dioxolane-4-methanamin

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Technology Process of (4S,5R)-5-[(chloro-diphenyl)methyl]-N,N,2,2-tetramethyl-α,α-diphenyl-1,3-dioxolane-4-methanamin

There total 3 articles about (4S,5R)-5-[(chloro-diphenyl)methyl]-N,N,2,2-tetramethyl-α,α-diphenyl-1,3-dioxolane-4-methanamin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 147700-71-8
(4R,5S)-2,2-dimethyl-5-(dimethylamino-diphenyl-methyl)-α,α-diphenyl-1,3-dioxolan-4-methanol

: 193892-73-8
(4S,5R)-5-[(chloro-diphenyl)methyl]-N,N,2,2-tetramethyl-α,α-diphenyl-1,3-dioxolane-4-methanamin

Guidance literature:: With thionyl chloride; lithium chloride; In tetrahydrofuran; Reflux;
DOI:10.1002/hlca.201200146

Reference yield:

: 93379-48-7
(R,R)-TADDOL

: 193892-73-8
(4S,5R)-5-[(chloro-diphenyl)methyl]-N,N,2,2-tetramethyl-α,α-diphenyl-1,3-dioxolane-4-methanamin

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NEt₃, 2.) methanesulfonyl chloride, 3.) H₂O / 1.) CH₂Cl₂, 5 min, 2.) CH₂Cl₂, 3 h

2: 67 percent / 8250.7 Torr / autoclave, 30 min, RT; 90 deg C, 5 h

3: 81 percent / SOCl₂ / CH₂Cl₂ / 0.5 h / Heating

With thionyl chloride; water; methanesulfonyl chloride; triethylamine; In dichloromethane;

Reference yield:

: 147700-67-2
(4R,5R)-5-[(chloro)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanol

: 193892-73-8
(4S,5R)-5-[(chloro-diphenyl)methyl]-N,N,2,2-tetramethyl-α,α-diphenyl-1,3-dioxolane-4-methanamin

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / 8250.7 Torr / autoclave, 30 min, RT; 90 deg C, 5 h

2: 81 percent / SOCl₂ / CH₂Cl₂ / 0.5 h / Heating

With thionyl chloride; In dichloromethane;