6-{1-[(4-methyl phenyl)sulfonyl]-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-(phenylsulfonyl)-1H-indazol-4-amine

Base Information

Chemical Name:6-{1-[(4-methyl phenyl)sulfonyl]-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-(phenylsulfonyl)-1H-indazol-4-amine
CAS No.:1310556-80-9
Molecular Formula:C₂₆H₂₀N₆O₄S₂
Molecular Weight:544.615
Hs Code.:

Synonyms:6-{1-[(4-methyl phenyl)sulfonyl]-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-(phenylsulfonyl)-1H-indazol-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-{1-[(4-methyl phenyl)sulfonyl]-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-(phenylsulfonyl)-1H-indazol-4-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-{1-[(4-methyl phenyl)sulfonyl]-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-(phenylsulfonyl)-1H-indazol-4-amine

There total 6 articles about 6-{1-[(4-methyl phenyl)sulfonyl]-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-(phenylsulfonyl)-1H-indazol-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1198437-73-8
1-((4-phenyl)sulfonyl)-6-(trimethylstannyl)-1H-indazol-4-amine

: 1309785-56-5
5-bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrazolo[3,4-b]pyridine

: 1310556-80-9
6-{1-[(4-methyl phenyl)sulfonyl]-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-(phenylsulfonyl)-1H-indazol-4-amine

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 120 ℃; for 4h; microwave;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1310556-80-9
6-{1-[(4-methyl phenyl)sulfonyl]-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-(phenylsulfonyl)-1H-indazol-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

1.2: Cooling with ice

1.3: 20 °C

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 1 h / 120 °C / microwave irradiation

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 120 °C / microwave

With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 875781-17-2,916257-29-9
5-bromo-7-azaindazole

: 1310556-80-9
6-{1-[(4-methyl phenyl)sulfonyl]-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-(phenylsulfonyl)-1H-indazol-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.92 h / Cooling with ice; Inert atmosphere

1.2: Cooling with ice; Inert atmosphere

1.3: Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 120 °C / microwave

With sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; mineral oil;