C₂₂H₂₄O₃

Base Information

• Chemical Name: C₂₂H₂₄O₃
• CAS No.: 1453470-68-2
• Molecular Formula: C₂₂H₂₄O₃
• Molecular Weight: 336.431
• Mol file: 1453470-68-2.mol

Synonyms:C₂₂H₂₄O₃

Chemical Property of C₂₂H₂₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₄O₃

There total 6 articles about C₂₂H₂₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-(tert-butyldimethylsilyloxy)-1-(dimethyl(phenyl)silyl)-4-phenylbutan-1-one (1453470-22-8) + 6-(tert-butyldimethylsilyloxy)-6-phenylhex-1-en-3-one (1453470-35-3) → C22H24O3 (1453470-68-2)

Guidance literature:

4-(tert-butyldimethylsilyloxy)-1-(dimethyl(phenyl)silyl)-4-phenylbutan-1-one; 6-(tert-butyldimethylsilyloxy)-6-phenylhex-1-en-3-one; With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; Inert atmosphere;

With camphor-10-sulfonic acid; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/ol402017x

Reference yield: 60.0%

C34H54O4Si2 (1453470-51-3) → C22H24O3 (1453470-68-2)

Guidance literature:

With camphor-10-sulfonic acid; In acetonitrile;

DOI:10.1021/ol402017x

Reference yield:

4-(tert-butyldimethylsilyloxy)-N-methoxy-N-methyl-4-phenylbutanamide (1453470-27-3) → C22H24O3 (1453470-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran; diethyl ether / 19 h / -80 °C

2.1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; isopropyl alcohol / 20 °C / Inert atmosphere

2.2: 20 °C

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; diethyl ether; isopropyl alcohol;

DOI:10.1021/ol402017x

upstream raw materials:

4-(tert-butyldimethylsilyloxy)-1-morpholino-4-phenylbutan-1-one

4-(tert-butyldimethylsilyloxy)-1-(dimethyl(phenyl)silyl)-4-phenylbutan-1-one

6-(tert-butyldimethylsilyloxy)-6-phenylhex-1-en-3-one

4-(tert-butyldimethylsilyloxy)-N-methoxy-N-methyl-4-phenylbutanamide