4-(tert-butyldimethylsilyloxy)-1-morpholino-4-phenylbutan-1-one

Base Information

• Chemical Name: 4-(tert-butyldimethylsilyloxy)-1-morpholino-4-phenylbutan-1-one
• CAS No.: 1453470-16-0
• Molecular Formula: C₂₀H₃₃NO₃Si
• Molecular Weight: 363.572
• Mol file: 1453470-16-0.mol

Synonyms:4-(tert-butyldimethylsilyloxy)-1-morpholino-4-phenylbutan-1-one

Chemical Property of 4-(tert-butyldimethylsilyloxy)-1-morpholino-4-phenylbutan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(tert-butyldimethylsilyloxy)-1-morpholino-4-phenylbutan-1-one

There total 1 articles about 4-(tert-butyldimethylsilyloxy)-1-morpholino-4-phenylbutan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

morpholine (110-91-8,99108-56-2) + 3-phenyldihydrofuran-2-one (6836-98-2) + tert-butyldimethylsilyl chloride (18162-48-6) → 4-(tert-butyldimethylsilyloxy)-1-morpholino-4-phenylbutan-1-one (1453470-16-0)

Guidance literature:

morpholine; 3-phenyldihydrofuran-2-one; at 110 ℃; for 5 - 8h;

tert-butyldimethylsilyl chloride; With pyridine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1021/ol402017x

Reference yield: 90.0%

4-(tert-butyldimethylsilyloxy)-1-morpholino-4-phenylbutan-1-one (1453470-16-0) + dimethyl(phenyl)silyllithium (3839-31-4) → 4-(tert-butyldimethylsilyloxy)-1-(dimethyl(phenyl)silyl)-4-phenylbutan-1-one (1453470-22-8)

Guidance literature:

In tetrahydrofuran; at -80 ℃; for 14h;

DOI:10.1021/ol402017x

Reference yield:

4-(tert-butyldimethylsilyloxy)-1-morpholino-4-phenylbutan-1-one (1453470-16-0) → C22H24O3 (1453470-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 14 h / -80 °C

2.1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; isopropyl alcohol / 20 °C / Inert atmosphere

2.2: 20 °C

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; isopropyl alcohol;

DOI:10.1021/ol402017x

upstream raw materials:

morpholine

3-phenyldihydrofuran-2-one

tert-butyldimethylsilyl chloride

Downstream raw materials:

C₂₉H₅₂O₄Si₂

C₃₄H₅₄O₄Si₂

C₃₀H₅₄O₄Si₂

7-(tert-butyldimethylsilyloxy)-7-phenyl-4-oxoheptanenitrile