1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid

Base Information

Chemical Name:1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid
CAS No.:115173-30-3
Molecular Formula:C₂₁H₁₇N₃O₃S
Molecular Weight:391.45
Hs Code.:

Synonyms:1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid

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Chemical Property of 1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid

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Technology Process of 1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid

There total 5 articles about 1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 115173-13-2
1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

: 115173-30-3
1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:: With potassium hydroxide; In water; for 1h; Heating;
DOI:10.1002/jhet.5570240604

Reference yield:

: 63463-10-5
diethyl 3-acetylanilinomethylenemalonate

: 115173-30-3
1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: Dowtherm A / 0.5 h / 250 - 254 °C

2: potassium carbonate, tetra-n-butylammonium bromide / CHCl₃; H₂O / 5 h / Heating

3: 78 percent / potassium bromate, hydrobromic acid / acetic acid / 24 h

4: 2) triethylamine / 1) overnight, room temp., 2) 1h

5: 100 percent / 1N potassium hydroxide / H₂O / 1 h / Heating

With potassium bromate; potassium hydroxide; diphenyl ether-biphenyl eutectic; tetrabutylammomium bromide; hydrogen bromide; potassium carbonate; triethylamine; In chloroform; water; acetic acid;
DOI:10.1002/jhet.5570240604

Reference yield:

: 115172-91-3
7-acetyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

: 115173-30-3
1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate, tetra-n-butylammonium bromide / CHCl₃; H₂O / 5 h / Heating

2: 78 percent / potassium bromate, hydrobromic acid / acetic acid / 24 h

3: 2) triethylamine / 1) overnight, room temp., 2) 1h

4: 100 percent / 1N potassium hydroxide / H₂O / 1 h / Heating

With potassium bromate; potassium hydroxide; tetrabutylammomium bromide; hydrogen bromide; potassium carbonate; triethylamine; In chloroform; water; acetic acid;
DOI:10.1002/jhet.5570240604