1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

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Chemical Name:1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
CAS No.:115173-13-2
Molecular Formula:C₂₃H₂₁N₃O₃S
Molecular Weight:419.504
Hs Code.:

Synonyms:1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

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Chemical Property of 1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

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Technology Process of 1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

There total 4 articles about 1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63463-10-5
diethyl 3-acetylanilinomethylenemalonate

: 115173-13-2
1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Dowtherm A / 0.5 h / 250 - 254 °C

2: potassium carbonate, tetra-n-butylammonium bromide / CHCl₃; H₂O / 5 h / Heating

3: 78 percent / potassium bromate, hydrobromic acid / acetic acid / 24 h

4: 2) triethylamine / 1) overnight, room temp., 2) 1h

With potassium bromate; diphenyl ether-biphenyl eutectic; tetrabutylammomium bromide; hydrogen bromide; potassium carbonate; triethylamine; In chloroform; water; acetic acid;
DOI:10.1002/jhet.5570240604

Reference yield:

: 115172-91-3
7-acetyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

: 115173-13-2
1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate, tetra-n-butylammonium bromide / CHCl₃; H₂O / 5 h / Heating

2: 78 percent / potassium bromate, hydrobromic acid / acetic acid / 24 h

3: 2) triethylamine / 1) overnight, room temp., 2) 1h

With potassium bromate; tetrabutylammomium bromide; hydrogen bromide; potassium carbonate; triethylamine; In chloroform; water; acetic acid;
DOI:10.1002/jhet.5570240604

Reference yield:

: 115172-90-2
7-acetyl-1-ethyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, ethyl ester

: 115173-13-2
1-Ethyl-4-oxo-7-(2-phenylamino-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / potassium bromate, hydrobromic acid / acetic acid / 24 h

2: 2) triethylamine / 1) overnight, room temp., 2) 1h

With potassium bromate; hydrogen bromide; triethylamine; In acetic acid;
DOI:10.1002/jhet.5570240604