Technology Process of 4,6-di-O-benzoyl-3-O-benzyl-1-thio-α-D-arabino-hexopyranosid-2-ulosyl bromide
There total 6 articles about 4,6-di-O-benzoyl-3-O-benzyl-1-thio-α-D-arabino-hexopyranosid-2-ulosyl bromide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) NaH, tetrabutylammonium iodide / 1.) THF, 0 deg C -> room temperature, 2.) THF, 50 deg C, 2 h
2: 81 percent / Dowex 50 (H(1+)) / H2O / 2 h / 70 °C
3: 23.2 g / pyridine / CHCl3 / 24 h / Ambient temperature
4: hydrogen bromide, acetic acid / CH2Cl2 / 0.17 h
5: 3.28 g / 1,8-diazabicyclo<5.4.0>undec-7-ene / CH2Cl2 / 1.5 h / Ambient temperature
6: 96 percent / molecular sieves 4A, ethanol, N-bromosuccinimide / CH2Cl2 / 0.5 h
With
pyridine; N-Bromosuccinimide; ethanol; 4 A molecular sieve; Dowex 50 (H(1+)); hydrogen bromide; tetra-(n-butyl)ammonium iodide; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
dichloromethane; chloroform; water;
DOI:10.1016/S0008-6215(97)00249-8
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 81 percent / Dowex 50 (H(1+)) / H2O / 2 h / 70 °C
2: 23.2 g / pyridine / CHCl3 / 24 h / Ambient temperature
3: hydrogen bromide, acetic acid / CH2Cl2 / 0.17 h
4: 3.28 g / 1,8-diazabicyclo<5.4.0>undec-7-ene / CH2Cl2 / 1.5 h / Ambient temperature
5: 96 percent / molecular sieves 4A, ethanol, N-bromosuccinimide / CH2Cl2 / 0.5 h
With
pyridine; N-Bromosuccinimide; ethanol; 4 A molecular sieve; Dowex 50 (H(1+)); hydrogen bromide; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
dichloromethane; chloroform; water;
DOI:10.1016/S0008-6215(97)00249-8
