1-{4'-[5-((R)-1,2-dimethyl-propoxycarbonylamino)-1-methyl-1H-[1,2,3]triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

Base Information

Chemical Name:1-{4'-[5-((R)-1,2-dimethyl-propoxycarbonylamino)-1-methyl-1H-[1,2,3]triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid
CAS No.:1396007-69-4
Molecular Formula:C₂₅H₂₈N₄O₄
Molecular Weight:448.522
Hs Code.:

Synonyms:1-{4'-[5-((R)-1,2-dimethyl-propoxycarbonylamino)-1-methyl-1H-[1,2,3]triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

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Chemical Property of 1-{4'-[5-((R)-1,2-dimethyl-propoxycarbonylamino)-1-methyl-1H-[1,2,3]triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

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Technology Process of 1-{4'-[5-((R)-1,2-dimethyl-propoxycarbonylamino)-1-methyl-1H-[1,2,3]triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

There total 6 articles about 1-{4'-[5-((R)-1,2-dimethyl-propoxycarbonylamino)-1-methyl-1H-[1,2,3]triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.3%

: 1-{4'-[5-((R)-1,2-dimethyl-propoxycarbonylamino)-1-methyl-1H-[1,2,3]triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

: 1396007-69-4
1-{4'-[5-((R)-1,2-dimethyl-propoxycarbonylamino)-1-methyl-1H-[1,2,3]triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃;

Reference yield:

: 766-96-1
4-bromo-1-ethynylbenzene

: 1396007-69-4
1-{4'-[5-((R)-1,2-dimethyl-propoxycarbonylamino)-1-methyl-1H-[1,2,3]triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -70 °C

1.2: 2 h / -70 - 20 °C

2.1: benzene / 4 h / Reflux

3.1: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 0.17 h / 0 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

5.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 90 °C

6.1: XPhos; palladium diacetate; potassium phosphate / toluene; water / 2 h / 95 °C / Inert atmosphere

7.1: water; sodium hydroxide / ethanol; tetrahydrofuran / 20 °C

With potassium phosphate; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; water; palladium diacetate; triethylamine; sodium hydroxide; lithium hydroxide; lithium diisopropyl amide; XPhos; In tetrahydrofuran; ethanol; water; toluene; benzene;

Reference yield:

: (4-bromo-phenyl)propynoic acid ethyl ester

: 1396007-69-4
1-{4'-[5-((R)-1,2-dimethyl-propoxycarbonylamino)-1-methyl-1H-[1,2,3]triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: benzene / 4 h / Reflux

2: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 0.17 h / 0 °C

3: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

4: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 90 °C

5: XPhos; palladium diacetate; potassium phosphate / toluene; water / 2 h / 95 °C / Inert atmosphere

6: water; sodium hydroxide / ethanol; tetrahydrofuran / 20 °C

With potassium phosphate; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; water; palladium diacetate; triethylamine; sodium hydroxide; lithium hydroxide; XPhos; In tetrahydrofuran; ethanol; water; toluene; benzene;