1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid methyl ester

Base Information

• Chemical Name: 1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid methyl ester
• CAS No.: 1396007-85-4
• Molecular Formula: C17H23BO4
• Molecular Weight: 302.178
• Mol file: 1396007-85-4.mol

Synonyms:1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid methyl ester;methyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylate

Chemical Property of 1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid methyl ester

Chemical Property:

• Boiling Point: 386.4±35.0 °C(Predicted)
• PSA: 44.76000
• Density: 1.11±0.1 g/cm3(Predicted)
• LogP: 2.19040

Purity/Quality:

98% ^*data from raw suppliers

Methyl1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid methyl ester

There total 4 articles about 1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.9%

1-(4-bromophenyl)-cyclopropanecarboxylic acid methyl ester (638220-35-6) + bis(pinacol)diborane (73183-34-3) → 1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid methyl ester (1396007-85-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 80 ℃; for 4h; Inert atmosphere;

Reference yield:

1-(4-bromophenyl)cyclopropanecarboxylic acid (345965-52-8) → 1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid methyl ester (1396007-85-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 4 h / 65 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; In 1,4-dioxane;

Reference yield:

4-Bromophenylacetonitrile (16532-79-9) → 1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid methyl ester (1396007-85-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrabutylammomium bromide; potassium hydroxide / water; toluene / 65 °C

2.1: potassium hydroxide / ethylene glycol / 6 h / 160 °C

2.2: pH 3 - 4

3.1: sulfuric acid / 4 h / 65 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; tetrabutylammomium bromide; potassium hydroxide; In 1,4-dioxane; water; ethylene glycol; toluene;

upstream raw materials:

4-Bromophenylacetonitrile

1-(4-bromophenyl)cyclopropanecarbonitrile

1-(4-bromophenyl)cyclopropanecarboxylic acid

1-(4-bromophenyl)-cyclopropanecarboxylic acid methyl ester

Downstream raw materials:

1-{4'-[5-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,3]triazol-1-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid methyl ester

1-{4'-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]-triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

1-{4'-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

1-{4'-[5-((R)-1,2-dimethyl-propoxycarbonylamino)-1-methyl-1H-[1,2,3]triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1396007-85-4 1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send