4-Ethyl-1-<1(H)-indol-3-ylacetyl>-3-(1,3-dimethyl-4,5-diphenylimidazolidin-2-yl)-1,4-dihydropyridine

Base Information

Chemical Name:4-Ethyl-1-<1(H)-indol-3-ylacetyl>-3-(1,3-dimethyl-4,5-diphenylimidazolidin-2-yl)-1,4-dihydropyridine
CAS No.:133621-67-7
Molecular Formula:C₃₄H₃₆N₄O
Molecular Weight:516.686
Hs Code.:

Synonyms:4-Ethyl-1-<1(H)-indol-3-ylacetyl>-3-(1,3-dimethyl-4,5-diphenylimidazolidin-2-yl)-1,4-dihydropyridine

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Chemical Property of 4-Ethyl-1-<1(H)-indol-3-ylacetyl>-3-(1,3-dimethyl-4,5-diphenylimidazolidin-2-yl)-1,4-dihydropyridine

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Technology Process of 4-Ethyl-1-<1(H)-indol-3-ylacetyl>-3-(1,3-dimethyl-4,5-diphenylimidazolidin-2-yl)-1,4-dihydropyridine

There total 4 articles about 4-Ethyl-1-<1(H)-indol-3-ylacetyl>-3-(1,3-dimethyl-4,5-diphenylimidazolidin-2-yl)-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 50720-05-3
indolyl acetyl chloride

: 18365-11-2
ethyl copper

: 133634-31-8
3-(1,3-Dimethyl-4(S),5(S)-diphenylimidazolidin-2-yl)pyridine

: 133621-67-7
4-Ethyl-1-<1(H)-indol-3-ylacetyl>-3-(1,3-dimethyl-4,5-diphenylimidazolidin-2-yl)-1,4-dihydropyridine

Guidance literature:: With lithium bromide; In tetrahydrofuran;
DOI:10.1016/0040-4039(91)80605-6

Reference yield:

: 500-22-1
3-pyridinecarboxaldehyde

: 133621-67-7
4-Ethyl-1-<1(H)-indol-3-ylacetyl>-3-(1,3-dimethyl-4,5-diphenylimidazolidin-2-yl)-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / molecular sieves 4 Angstroem / diethyl ether / 0.33 h / Ambient temperature

2: 1.) CuBr, Me₂S, LiBr / 1.) THF, 2.) -60 deg C, 6 h

With dimethylsulfide; 4 A molecular sieve; copper(I) bromide; lithium bromide; In diethyl ether;
DOI:10.1021/jo00086a045

Reference yield:

: 22751-68-4,60508-97-6,60509-62-8,70749-06-3,118628-68-5
(S,S)-N,N'-dimethyl-1,2-diphenylethane-1,2-diamine

: 133621-67-7
4-Ethyl-1-<1(H)-indol-3-ylacetyl>-3-(1,3-dimethyl-4,5-diphenylimidazolidin-2-yl)-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / molecular sieves 4 Angstroem / diethyl ether / 0.33 h / Ambient temperature

2: 1.) CuBr, Me₂S, LiBr / 1.) THF, 2.) -60 deg C, 6 h

With dimethylsulfide; 4 A molecular sieve; copper(I) bromide; lithium bromide; In diethyl ether;
DOI:10.1021/jo00086a045