Technology Process of pyrazine-2-carboxylic acid [3-(6-methanesulfonylaminocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-amide
There total 8 articles about pyrazine-2-carboxylic acid [3-(6-methanesulfonylaminocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-amide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-pyrazylcarboxylic acid;
With
1,1'-carbonyldiimidazole;
In
N,N-dimethyl-formamide;
at 70 ℃;
for 1h;
N-[2-(3-Amino-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl]-methanesulfonamide;
In
N,N-dimethyl-formamide;
at 25 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: toluene-4-sulfonic acid / toluene / 3 h / Reflux
2.1: water / ytterbium(III) trifluoromethanesulfonate hydrate / tetrahydrofuran / 16 h / 25 °C
3.1: trifluoroacetic acid; triethylsilane / 3 h / 25 °C
4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 12 h / 60 °C
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 25 °C
5.2: 1 h / 25 °C
6.1: hydrogenchloride; iron / ethanol; water / 1 h / 95 °C
7.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 70 °C
7.2: 1 h / 25 °C
With
hydrogenchloride; triethylsilane; water; iron; sodium hydride; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; trifluoroacetic acid; sodium hydroxide;
ytterbium(III) trifluoromethanesulfonate hydrate;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil;
2.1: Diels-Alder Reaction;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: toluene-4-sulfonic acid / toluene / 3 h / Reflux
2.1: water / ytterbium(III) trifluoromethanesulfonate hydrate / tetrahydrofuran / 16 h / 25 °C
3.1: trifluoroacetic acid; triethylsilane / 3 h / 25 °C
4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 12 h / 60 °C
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 25 °C
5.2: 1 h / 25 °C
6.1: hydrogenchloride; iron / ethanol; water / 1 h / 95 °C
7.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 70 °C
7.2: 1 h / 25 °C
With
hydrogenchloride; triethylsilane; water; iron; sodium hydride; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; trifluoroacetic acid; sodium hydroxide;
ytterbium(III) trifluoromethanesulfonate hydrate;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil;
2.1: Diels-Alder Reaction;
