4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]benzaldehyde

Base Information

• Chemical Name: 4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]benzaldehyde
• CAS No.: 934765-62-5
• Molecular Formula: C₁₃H₉FN₂O₄
• Molecular Weight: 276.224
• Mol file: 934765-62-5.mol

Synonyms:4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]benzaldehyde

Chemical Property of 4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]benzaldehyde

There total 2 articles about 4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + 2-nitro-4-fluoro-5-chloroaniline (104222-34-6) → 4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]benzaldehyde (934765-62-5)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 80 ℃; for 6h;

Reference yield:

4,5-difluoro-2-nitroaniline (78056-39-0) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]benzaldehyde (934765-62-5)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In toluene; for 2h; Reflux;

DOI:10.1039/c3md00022b

Reference yield:

4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]benzaldehyde (934765-62-5) + di-tert-butyl dicarbonate (24424-99-5) + 4,4-dimethyl-1-cyclohexylamine (20615-18-3) → 1,1-dimethylethyl({4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]phenyl}methyl)(4,4-dimethylcyclohexyl)carbamate (934765-63-6)

Guidance literature:

4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]benzaldehyde; 4,4-dimethyl-1-cyclohexylamine; With sodium cyanoborohydride; acetic acid; In methanol;

With water; In methanol;

di-tert-butyl dicarbonate; With sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃; for 6h;

upstream raw materials:

4-hydroxy-benzaldehyde

2-nitro-4-fluoro-5-chloroaniline

4,5-difluoro-2-nitroaniline

Downstream raw materials:

1,1-dimethylethyl({4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]phenyl}methyl)(4,4-dimethylcyclohexyl)carbamate

2,2,2-trifluoro-N-[4-fluoro-5-[(4-formylphenyl)oxy]-2-nitrophenyl]acetamide