1,1-dimethylethyl({4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]phenyl}methyl)(4,4-dimethylcyclohexyl)carbamate

Base Information

• Chemical Name: 1,1-dimethylethyl({4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]phenyl}methyl)(4,4-dimethylcyclohexyl)carbamate
• CAS No.: 934765-63-6
• Molecular Formula: C₂₆H₃₄FN₃O₅
• Molecular Weight: 487.571
• Mol file: 934765-63-6.mol

Synonyms:1,1-dimethylethyl({4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]phenyl}methyl)(4,4-dimethylcyclohexyl)carbamate

Chemical Property of 1,1-dimethylethyl({4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]phenyl}methyl)(4,4-dimethylcyclohexyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl({4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]phenyl}methyl)(4,4-dimethylcyclohexyl)carbamate

There total 1 articles about 1,1-dimethylethyl({4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]phenyl}methyl)(4,4-dimethylcyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]benzaldehyde (934765-62-5) + di-tert-butyl dicarbonate (24424-99-5) + 4,4-dimethyl-1-cyclohexylamine (20615-18-3) → 1,1-dimethylethyl({4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]phenyl}methyl)(4,4-dimethylcyclohexyl)carbamate (934765-63-6)

Guidance literature:

4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]benzaldehyde; 4,4-dimethyl-1-cyclohexylamine; With sodium cyanoborohydride; acetic acid; In methanol;

With water; In methanol;

di-tert-butyl dicarbonate; With sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃; for 6h;

Reference yield:

1,1-dimethylethyl({4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]phenyl}methyl)(4,4-dimethylcyclohexyl)carbamate (934765-63-6) + trifluoroacetic acid (76-05-1) → N-({4-[(5-fluoro-1H-benzimidazol-6-yl)oxy]phenyl}methyl)-4,4-dimethylcyclohexanamine trifluoroacetate (934764-98-4)

Guidance literature:

1,1-dimethylethyl({4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]phenyl}methyl)(4,4-dimethylcyclohexyl)carbamate; With hydrogen; acetic acid; palladium 10% on activated carbon; In ethanol; for 3h;

With sodium hydroxide; water;

trifluoroacetic acid; In dichloromethane; for 1h;

Reference yield:

1,1-dimethylethyl({4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]phenyl}methyl)(4,4-dimethylcyclohexyl)carbamate (934765-63-6) + formyl acetic anhydride (2258-42-6) → 1,1-dimethylethyl (4,4-dimethylcyclohexyl)[(4-{[2-fluoro-5-(formylamino)-4-nitrophenyl]oxy}phenyl)methyl]carbamate

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 1h;

upstream raw materials:

4-[(5-amino-2-fluoro-4-nitrophenyl)oxy]benzaldehyde

di-tert-butyl dicarbonate

4,4-dimethyl-1-cyclohexylamine

Downstream raw materials:

N-({4-[(5-fluoro-1H-benzimidazol-6-yl)oxy]phenyl}methyl)-4,4-dimethylcyclohexanamine trifluoroacetate