1-(4-fluorophenyl)-1-(3-oxopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Base Information

Chemical Name:1-(4-fluorophenyl)-1-(3-oxopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile
CAS No.:211800-31-6
Molecular Formula:C₁₈H₁₄FNO₂
Molecular Weight:295.313
Hs Code.:

Synonyms:1-(4-fluorophenyl)-1-(3-oxopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile

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Chemical Property of 1-(4-fluorophenyl)-1-(3-oxopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Chemical Property:

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Technology Process of 1-(4-fluorophenyl)-1-(3-oxopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile

There total 9 articles about 1-(4-fluorophenyl)-1-(3-oxopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 345663-54-9
1-(2-[1,3]-dioxolan-2-yl-ethyl)-1-(4-fluorophenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

: 211800-31-6
1-(4-fluorophenyl)-1-(3-oxopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Guidance literature:: With hydrogenchloride; water; In acetone; at 20 ℃; for 63h;

Reference yield:

: (±)-(E)-1-(4-fluorophenyl)-1-(3-oxoprop-1-en-1-yl)-1,3-dihydroisobenzofuran-5-carbonitrile

: 211800-31-6
1-(4-fluorophenyl)-1-(3-oxopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Guidance literature:: With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; (+/-)-2-(tert-butyl)-3-methylimidazolidin-4-one; trifluoroacetic acid; In chloroform; at 0 - 25 ℃; for 18h;
DOI:10.1021/acs.orglett.6b01253

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 211800-31-6
1-(4-fluorophenyl)-1-(3-oxopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: tetrahydrofuran; dichloromethane / 18 h / 0 - 25 °C

1.2: 2 h / 60 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.25 h

2.2: 48 h / 20 °C

3.1: sodium methylate / methanol / 18 h / 25 °C

4.1: 15 h / 25 °C

5.1: methylamine / ethanol / 2 h / 40 °C

6.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 1 h / 80 °C

7.1: tetrahydrofuran / 18 h / 0 - 40 °C

8.1: pyridinium p-toluenesulfonate / water; acetone / 18 h / Reflux

9.1: toluene-4-sulfonic acid / toluene / 1 h / Dean-Stark

10.1: (+/-)-2-(tert-butyl)-3-methylimidazolidin-4-one; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; trifluoroacetic acid / chloroform / 18 h / 0 - 25 °C

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; potassium tert-butylate; sodium methylate; pyridinium p-toluenesulfonate; (+/-)-2-(tert-butyl)-3-methylimidazolidin-4-one; toluene-4-sulfonic acid; methylamine; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; acetone; toluene; acetonitrile;
DOI:10.1021/acs.orglett.6b01253