5-acetyl-9-benzylamino-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine-7-carboxylic acid

Base Information

Chemical Name:5-acetyl-9-benzylamino-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine-7-carboxylic acid
CAS No.:492438-84-3
Molecular Formula:C₂₁H₁₈N₄O₄
Molecular Weight:390.398
Hs Code.:

Synonyms:5-acetyl-9-benzylamino-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine-7-carboxylic acid

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Chemical Property of 5-acetyl-9-benzylamino-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine-7-carboxylic acid

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Technology Process of 5-acetyl-9-benzylamino-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine-7-carboxylic acid

There total 12 articles about 5-acetyl-9-benzylamino-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 492438-83-2
5-acetyl-9-benzylamino-7-ethoxycarbonyl-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

: 492438-84-3
5-acetyl-9-benzylamino-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine-7-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h;
DOI:10.1021/jo026508x

Reference yield:

: 290332-96-6
ethyl α-azido-β-(4-methoxypyrid-3-yl)acrylate

: 492438-84-3
5-acetyl-9-benzylamino-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: 67 percent / o-xylene / 0.42 h / 170 °C

2.1: 94 percent / sodium hydride / dimethylformamide / 12 h / 20 °C

3.1: 93 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Heating

4.1: 86 percent / MnO₂ / CH₂Cl₂ / 72 h / 20 °C

5.1: 85 percent / Na / ethanol / 72 h / -15 °C

6.1: 82 percent / CH₂Cl₂ / 24 h / 20 °C

7.1: 70 percent / Bu₄NF/SiO₂ / 0.03 h / microwave irradiation

8.1: 97 percent / tetrahydrofuran / 24 h / 50 °C

9.1: POCl₃ / CHCl₃ / 0.42 h / 20 °C

9.2: 90 percent / CHCl₃ / 30 h / 70 °C

10.1: 100 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 2 h / 20 °C

With manganese(IV) oxide; lithium hydroxide; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; sodium; silica gel; sodium hydride; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; chloroform; o-xylene; water; N,N-dimethyl-formamide; 6.1: Staudinger reaction;
DOI:10.1021/jo026508x

Reference yield:

: 290333-00-5
[4-methoxy-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-methanol

: 492438-84-3
5-acetyl-9-benzylamino-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 86 percent / MnO₂ / CH₂Cl₂ / 72 h / 20 °C

2.1: 85 percent / Na / ethanol / 72 h / -15 °C

3.1: 82 percent / CH₂Cl₂ / 24 h / 20 °C

4.1: 70 percent / Bu₄NF/SiO₂ / 0.03 h / microwave irradiation

5.1: 97 percent / tetrahydrofuran / 24 h / 50 °C

6.1: POCl₃ / CHCl₃ / 0.42 h / 20 °C

6.2: 90 percent / CHCl₃ / 30 h / 70 °C

7.1: 100 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 2 h / 20 °C

With manganese(IV) oxide; lithium hydroxide; tetrabutyl ammonium fluoride; sodium; silica gel; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; 3.1: Staudinger reaction;
DOI:10.1021/jo026508x